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Table 5 Hazard ratios of ER+PR+ and ER-PR- tumors for categories of postmenopausal HRT use within tertiles of BMI.

From: Adiposity, hormone replacement therapy use and breast cancer risk by age and hormone receptor status: a large prospective cohort study

BMI tertile3 HRT use  
  Never user Past user Current user  
  Cases Reference Cases HR 95% CI Cases HR 95% CI P interaction 2
ER+PR+          
Age and center stratified          
BMI tertile 1 125 1.00 49 1.18 (0.84-1.65) 296 2.33 (1.84-2.92) < 0.001
BMI tertile 2 248 1.00 81 1.10 (0.85-1.42) 312 1.75 (1.45-2.12)  
BMI tertile 3 392 1.00 95 1.11 (0.88-1.39) 200 1.45 (1.19-1.77)  
ER+PR+          
Multivariable model 3          
BMI tertile 1 125 1.00 49 1.17 (0.83-1.64) 296 2.32 (1.84-2.92) < 0.001
BMI tertile 2 248 1.00 81 1.10 (0.85-1.42) 312 1.75 (1.45-2.11)  
BMI tertile 3 392 1.00 95 1.11 (0.88-1.39) 200 1.45 (1.19-1.76)  
ER-PR-          
Age and center stratified          
BMI tertile 1 41 1.00 19 1.38 (0.79-2.43) 79 1.74 (1.15-2.63) 0.037
BMI tertile 2 80 1.00 29 1.20 (0.78-1.86) 69 1.07 (0.75-1.54)  
BMI tertile 3 103 1.00 20 0.92 (0.57-1.51) 45 1.21 (0.81-1.81)  
ER-PR-          
Multivariable model          
BMI tertile 1 41 1.00 19 1.38 (0.79-2.43) 79 1.74 (1.15-2.63) 0.037
BMI tertile 2 80 1.00 29 1.18 (0.77-1.83) 69 1.08 (0.75-1.55)  
BMI tertile 3 103 1.00 20 0.92 (0.57-1.51) 45 1.21 (0.81-1.81)  
  1. 1BMI tertile 1: ≤22.5 kg/m2; BMI tertile 2: 22.6 to 25.8 kg/m2; BMI tertile 3: ≥25.9 kg/m2; 2P for interaction was calculated using the log likelihood ratio test for models with and without the interaction term for HRT never and current use by BMI tertiles; 3multivariable hazard ratios were stratified for study center, age, and adjusted for height (cm), educational attainment, smoking status, alcohol consumption, parity, age at first pregnancy, ever OC use, age at menarche, menopausal status, age at menopause. BMI, body mass index; CI, confidence interval; ER, estrogen receptor; HR, hazard ratio; HRT, hormone replacement therapy; PR, progesterone receptor.