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Table 5 Hazard ratios of ER+PR+ and ER-PR- tumors for categories of postmenopausal HRT use within tertiles of BMI.

From: Adiposity, hormone replacement therapy use and breast cancer risk by age and hormone receptor status: a large prospective cohort study

BMI tertile3

HRT use

 
 

Never user

Past user

Current user

 
 

Cases

Reference

Cases

HR

95% CI

Cases

HR

95% CI

P interaction 2

ER+PR+

         

Age and center stratified

         

BMI tertile 1

125

1.00

49

1.18

(0.84-1.65)

296

2.33

(1.84-2.92)

< 0.001

BMI tertile 2

248

1.00

81

1.10

(0.85-1.42)

312

1.75

(1.45-2.12)

 

BMI tertile 3

392

1.00

95

1.11

(0.88-1.39)

200

1.45

(1.19-1.77)

 

ER+PR+

         

Multivariable model 3

         

BMI tertile 1

125

1.00

49

1.17

(0.83-1.64)

296

2.32

(1.84-2.92)

< 0.001

BMI tertile 2

248

1.00

81

1.10

(0.85-1.42)

312

1.75

(1.45-2.11)

 

BMI tertile 3

392

1.00

95

1.11

(0.88-1.39)

200

1.45

(1.19-1.76)

 

ER-PR-

         

Age and center stratified

         

BMI tertile 1

41

1.00

19

1.38

(0.79-2.43)

79

1.74

(1.15-2.63)

0.037

BMI tertile 2

80

1.00

29

1.20

(0.78-1.86)

69

1.07

(0.75-1.54)

 

BMI tertile 3

103

1.00

20

0.92

(0.57-1.51)

45

1.21

(0.81-1.81)

 

ER-PR-

         

Multivariable model

         

BMI tertile 1

41

1.00

19

1.38

(0.79-2.43)

79

1.74

(1.15-2.63)

0.037

BMI tertile 2

80

1.00

29

1.18

(0.77-1.83)

69

1.08

(0.75-1.55)

 

BMI tertile 3

103

1.00

20

0.92

(0.57-1.51)

45

1.21

(0.81-1.81)

 
  1. 1BMI tertile 1: ≤22.5 kg/m2; BMI tertile 2: 22.6 to 25.8 kg/m2; BMI tertile 3: ≥25.9 kg/m2; 2P for interaction was calculated using the log likelihood ratio test for models with and without the interaction term for HRT never and current use by BMI tertiles; 3multivariable hazard ratios were stratified for study center, age, and adjusted for height (cm), educational attainment, smoking status, alcohol consumption, parity, age at first pregnancy, ever OC use, age at menarche, menopausal status, age at menopause. BMI, body mass index; CI, confidence interval; ER, estrogen receptor; HR, hazard ratio; HRT, hormone replacement therapy; PR, progesterone receptor.
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Breast Cancer Research

ISSN: 1465-542X

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