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Table 4 Hazard ratios of ER+PR+ and ER-PR- tumors across levels of BMI within categories of postmenopausal HRT users.

From: Adiposity, hormone replacement therapy use and breast cancer risk by age and hormone receptor status: a large prospective cohort study

HRT use

BMI tertile1

   
 

1

2

3

 

Per 5 kg/m 2 increase

 

Cases

Reference

Cases

HR

95% CI

Cases

HR

95% CI

Cases

  

ER+PR+

           

Age and center stratified

           

Never user

125

1.00

248

1.44

(1.15-1.78)

392

1.80

(1.46-2.23)

765

1.24

(1.15-1.34)

Past user

49

1.00

81

1.45

(1.01-2.09)

95

1.85

(1.27-2.69)

225

1.45

(1.25-1.68)

Current user

296

1.00

312

1.03

(0.87-1.21)

200

0.74

(0.50-1.09)

808

0.99

(0.89-1.09)

ER+PR+

           

Multivariable model 2

           

Never user

125

1.00

248

1.47

(1.18-1.82)

392

1.90

(1.53-2.35)

765

1.28

(1.18-1.38)

Past user

49

1.00

81

1.43

(0.99-2.07)

95

1.89

(1.29-2.77)

225

1.47

(1.26-1.72)

Current user

296

1.00

312

1.04

(0.88-1.23)

200

0.95

(0.78-1.15)

808

1.01

(0.91-1.12)

ER-PR-

           

Age and center stratified

           

Never user

41

1.00

80

1.40

(0.96-2.06)

103

1.47

(1.01-2.15)

224

1.07

(0.93-1.25)

Past user

19

1.00

29

1.20

(0.66-2.20)

69

0.80

(0.40-1.60)

117

0.86

(0.62-1.19)

Current user

79

1.00

69

0.82

(0.59-1.15)

45

0.74

(0.50-1.09)

193

0.79

(0.63-0.98)

ER-PR-

           

Multivariable model

           

Never user

41

1.00

80

1.44

(0.98-2.11)

103

1.59

(1.08-2.34)

224

1.12

(0.96-1.31)

Past user

19

1.00

29

1.18

(0.64-2.18)

69

0.76

(0.37-1.56)

117

0.82

(0.58-1.16)

Current user

79

1.00

69

0.82

(0.59-1.15)

45

0.77

(0.52-1.14)

193

0.80

(0.64-1.01)

  1. 1BMI tertile 1: ≤22.5 kg/m2; BMI tertile 2: 22.6 to 25.8 kg/m2; BMI tertile 3: ≥25.9 kg/m2; 2 multivariable hazard ratios were stratified for study center, age, and adjusted for height (cm), educational attainment, smoking status, alcohol consumption, parity, age at first pregnancy, age at menarche, ever OC use, menopausal status, age at menopause. BMI, body mass index; CI, confidence interval; ER, estrogen receptor; HR, hazard ratio; HRT, hormone replacement therapy; PR, progesterone receptor.
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Breast Cancer Research

ISSN: 1465-542X

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