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Table 4 Hazard ratios of ER+PR+ and ER-PR- tumors across levels of BMI within categories of postmenopausal HRT users.

From: Adiposity, hormone replacement therapy use and breast cancer risk by age and hormone receptor status: a large prospective cohort study

HRT use BMI tertile1    
  1 2 3   Per 5 kg/m 2 increase
  Cases Reference Cases HR 95% CI Cases HR 95% CI Cases   
ER+PR+            
Age and center stratified            
Never user 125 1.00 248 1.44 (1.15-1.78) 392 1.80 (1.46-2.23) 765 1.24 (1.15-1.34)
Past user 49 1.00 81 1.45 (1.01-2.09) 95 1.85 (1.27-2.69) 225 1.45 (1.25-1.68)
Current user 296 1.00 312 1.03 (0.87-1.21) 200 0.74 (0.50-1.09) 808 0.99 (0.89-1.09)
ER+PR+            
Multivariable model 2            
Never user 125 1.00 248 1.47 (1.18-1.82) 392 1.90 (1.53-2.35) 765 1.28 (1.18-1.38)
Past user 49 1.00 81 1.43 (0.99-2.07) 95 1.89 (1.29-2.77) 225 1.47 (1.26-1.72)
Current user 296 1.00 312 1.04 (0.88-1.23) 200 0.95 (0.78-1.15) 808 1.01 (0.91-1.12)
ER-PR-            
Age and center stratified            
Never user 41 1.00 80 1.40 (0.96-2.06) 103 1.47 (1.01-2.15) 224 1.07 (0.93-1.25)
Past user 19 1.00 29 1.20 (0.66-2.20) 69 0.80 (0.40-1.60) 117 0.86 (0.62-1.19)
Current user 79 1.00 69 0.82 (0.59-1.15) 45 0.74 (0.50-1.09) 193 0.79 (0.63-0.98)
ER-PR-            
Multivariable model            
Never user 41 1.00 80 1.44 (0.98-2.11) 103 1.59 (1.08-2.34) 224 1.12 (0.96-1.31)
Past user 19 1.00 29 1.18 (0.64-2.18) 69 0.76 (0.37-1.56) 117 0.82 (0.58-1.16)
Current user 79 1.00 69 0.82 (0.59-1.15) 45 0.77 (0.52-1.14) 193 0.80 (0.64-1.01)
  1. 1BMI tertile 1: ≤22.5 kg/m2; BMI tertile 2: 22.6 to 25.8 kg/m2; BMI tertile 3: ≥25.9 kg/m2; 2 multivariable hazard ratios were stratified for study center, age, and adjusted for height (cm), educational attainment, smoking status, alcohol consumption, parity, age at first pregnancy, age at menarche, ever OC use, menopausal status, age at menopause. BMI, body mass index; CI, confidence interval; ER, estrogen receptor; HR, hazard ratio; HRT, hormone replacement therapy; PR, progesterone receptor.