Crk adaptor proteins act as key signaling integrators for breast tumorigenesis

Breast Cancer Research

Table 1 Crk protein expression correlates with Ki67 within the basal subtype

Antibody	Correlation to Ki67 proliferation index (% cells Ki67 positive)
CrkI/II (TMA-1)	Correlation Coefficient	0.289
	P-value (2 tailed)	0.019
	number	43
CrkI/II (TMA-2)	Correlation Coefficient	0.323
	P-value (2 tailed)	0.016
	number	28
CrkII (TMA-2)	Correlation Coefficient	0.483
	P-value (2 tailed)	0.00024
	number	29
CrkL (C-20) (TMA-2)	Correlation Coefficient	0.483
	P-value (2 tailed)	0.00024
	number	29
CrkL (H-62) (TMA-2)	Correlation Coefficient	0.547
	P-value (2 tailed)	0.00003
	number	29

CrkI/II expression was examined in relation to Ki67 expression within 43 basal tumors using TMA-1. TMA-2 was utilized to examine Crk protein expression (using four different Crk antibodies recognizing CrkI/II, CrkII or CrkL) relative to Ki67 within 29 basal tumors. Kendall's tau non-parametric statistical analysis was used to assess for significance. TMA, tissue microarray.

ISSN: 1465-542X