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Figure 8 | Breast Cancer Research

Figure 8

From: Chromodomain helicase DNA binding protein 5 plays a tumor suppressor role in human breast cancer

Figure 8

CHD5 suppresses the invasion and the expression of EMT markers in breast cancer cells. (A, B) Expression of CHD5 inhibits the invasion of MDA-MB-231 cells (A) and Hs 578T cells (B), as detected in the invasion assay. CHD5 or control is indicated at the top, and sample names are indicated at upper left. (C-E) Detection of different proteins by Western blotting, including vimentin, p21 and p53 in MDA-MB-231 cells without transfection (Mock) or transfected with CHD5 plasmid (Smix population and S10 and S14 clones) or control plasmid (V1 and V2 clones) (C); N-cadherin, ZEB1 and vimentin in Hs 578T cell population expressing CHD5 (Smix) or vector (Vmix) (D); and E-cadherin, vimentin, p53 and p21 in T-47D cells without transfection (Mock) or transfected with negative control siRNA (Cont) and CHD5 siRNAs (Q7 and I20) (E).

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