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Table 5 Multivariate analyses for distant relapse in patients with estrogen receptor-positive disease in the JBI and MDA233 datasets.

From: Centromere protein-A, an essential centromere protein, is a prognostic marker for relapse in estrogen receptor-positive breast cancer

 

JBI (5 y DRFS)

MDA233 (RCB 0/1)

Variable

HR

95% CI

P-value

HR

95% CI

P-value

Age

0.99

0.95-1.03

0.48

1.02

0.98-1.06

0.38

T stage

2.09

0.89-4.89

0.09

3.22

0.35-30.01

0.30

Nodal status

0.99

0.47-2.08

0.98

0.39

0.15-1.00

0.05

Grade

0.79

0.31-2.00

0.61

1.09

0.41-2.89

0.86

ESR1

1.00

0.72-1.41

0.98

0.79

0.55-1.12

0.18

CENP-A

1.64

0.99-2.71

0.054

1.30

0.75-2.28

0.35

Ki-67

1.13

0.73-1.77

0.58

1.08

0.64-1.81

0.78

Her2/neu

0.94

0.67-1.31

0.71

1.05

0.67-1.64

0.84

  1. ESR1 (estrogen receptor alpha), CENP-A (centromere protein-A), Ki-67, and Her2/neu are continuous variables reflecting mRNA levels; HR, Hazard ratio; CI, confidence interval; DRFS, distant-relapse free survival; RCB, residual cancer burden
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Breast Cancer Research

ISSN: 1465-542X

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