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Table 1 Characteristics of families recruited into the TP53 study (n = 83)

From: Comparable frequency of BRCA1, BRCA2 and TP53 germline mutations in a multi-ethnic Asian cohort suggests TP53 screening should be offered together with BRCA1/2 screening to early-onset breast cancer patients

Characteristics No (%)
Ethnicity   
   Malay 29 35
   Chinese 44 53
   Indian 10 12
Family history (1° and 2° relatives)   
   1 case of breast cancer 13 16
   2 cases of breast cancer 3 4
   ≥ 3 cases of breast cancer 1 1
   No family history of breast and/or ovarian cancer 62 75
   ≥ 1 case of LFS-linked cancers 4 5
  1. Table 1 shows the characteristics of 83 BRCA-negative early-onset breast cancer patients analyzed for germline TP53mutations according to their ethnicity, personal and/or family history of breast cancer in first- and second-degree relatives and the presence of LFS-linked cancers (breast cancer, bone and soft tissue sarcoma, brain tumors, adrenocortical carcinoma (ACC)) in the families.