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Figure 1 | Breast Cancer Research

Figure 1

From: Comparable frequency of BRCA1, BRCA2 and TP53 germline mutations in a multi-ethnic Asian cohort suggests TP53 screening should be offered together with BRCA1/2 screening to early-onset breast cancer patients

Figure 1

Pedigrees of families with germline exonic mutations in TP53. Pedigrees of the following families: (a) Family BRC 901 with mutation TP53 p. E346X (b) Family BRC 564 with mutation TP53 p. G334_R335dup. (c) Family BRC 349 with mutation TP53 p. A138V (d) Family BRC 832 with mutation TP53 p. E285K (e) Family BRC 873 with mutation TP53 p. E285K. Index patients are indicated with an arrow. Individuals with cancer are indicated with filled symbol quadrants. Deceased individuals are indicated with a slash. Carriers with germline TP53 mutations are indicated with a "+" and non-carriers with a "-". ACC, adrenocortical carcinoma; Br ca, breast cancer; Bilat Br ca, bilateral breast cancer, CRC, colorectal cancer; ERMS, embryonal rhabdomyosarcoma; Uterine LMS, uterine leiomyosarcoma.

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