Pedigrees of families with germline exonic mutations in TP53. Pedigrees of the following families: (a) Family BRC 901 with mutation TP53 p. E346X (b) Family BRC 564 with mutation TP53 p. G334_R335dup. (c) Family BRC 349 with mutation TP53 p. A138V (d) Family BRC 832 with mutation TP53 p. E285K (e) Family BRC 873 with mutation TP53 p. E285K. Index patients are indicated with an arrow. Individuals with cancer are indicated with filled symbol quadrants. Deceased individuals are indicated with a slash. Carriers with germline TP53 mutations are indicated with a "+" and non-carriers with a "-". ACC, adrenocortical carcinoma; Br ca, breast cancer; Bilat Br ca, bilateral breast cancer, CRC, colorectal cancer; ERMS, embryonal rhabdomyosarcoma; Uterine LMS, uterine leiomyosarcoma.