Analysis of terminal duct lobular unit involution in luminal A and basal breast cancers

Breast Cancer Research

Table 1 Relationship between average number of acini per TDLU and tumor characteristics among women < 55 years old.

	Average number of acini (tertiles)*
Tumor characteristics	Low		Middle		High		OR (95% CI)**	P**
	N	%	N	%	N	%
Tumor size
≤ 2 cm	48	31.8	50	33.1	53	35.1	Ref
> 2 cm	40	31.0	40	31.0	49	38.0	1.15 (0.64, 2.06)	0.64
Axillary node metastases
Negative	54	34.2	47	29.7	57	36.1	Ref
Positive	32	27.1	41	34.8	45	38.1	1.31 (0.72, 2.38)	0.37
Histology
Ductal	49	27.5	56	31.5	73	41.0	Ref
Lobular	18	40.9	14	31.8	12	27.3	0.45 (0.20, 1.03)	0.06
Mixed	11	30.6	17	47.2	8	22.2	0.47 (0.17, 1.27)	0.13
Other	10	43.5	3	13.0	10	43.5	0.79 (0.30, 2.07)	0.62
Tumor grade
Well differentiated	25	36.2	19	27.5	25	36.2	Ref
Moderately differentiated	43	28.5	54	35.8	54	35.8	1.06 (0.56, 2.13)	0.88
Poorly differentiated	20	32.8	17	27.9	24	39.3	0.97 (0.42, 2.25)	0.95
ER
Negative	14	17.5	27	33.7	39	48.8	Ref
Positive	74	36.8	63	31.3	64	31.8	0.34 (0.17, 0.70)	0.003
PR
Negative	24	27.9	28	32.6	34	39.5	Ref
Positive	64	32.8	62	31.8	69	35.4	0.76 (0.40, 1.43)	0.39
CK5
Negative	72	34.6	64	30.8	72	34.6	Ref
Positive	16	22.9	24	34.3	30	42.9	1.72 (0.85, 3.49)	0.13
EGFR
Negative	79	34.1	78	33.6	75	32.3	Ref
Positive	9	19.1	10	21.3	28	59.6	2.78 (1.21, 6.39)	0.02

*Number of acini reflects averaged values from TDLUs per case in tertiles from lowest to highest; Number of acini per TDLU (1: 0 to 10, 2: 11 to 20, 3: 21 to 30, 4: 31 to 50, 5: 51 to 100, 6: > 100), low = 1 to 1.34; middle = 1.34 to 1.8; high = > 1.8. **P-values, ORs and 95% CIs were obtained from logistic regression analyses comparing cases with the highest to the lowest tertile of number of acini per TDLU adjusted for age and study site.

ISSN: 1465-542X