Skip to main content

Table 1 Relationship between average number of acini per TDLU and tumor characteristics among women < 55 years old.

From: Analysis of terminal duct lobular unit involution in luminal A and basal breast cancers

  Average number of acini (tertiles)*
Tumor characteristics Low Middle High OR (95% CI)** P**
  N % N % N %   
Tumor size         
   ≤ 2 cm 48 31.8 50 33.1 53 35.1 Ref  
   > 2 cm 40 31.0 40 31.0 49 38.0 1.15 (0.64, 2.06) 0.64
Axillary node metastases         
   Negative 54 34.2 47 29.7 57 36.1 Ref  
   Positive 32 27.1 41 34.8 45 38.1 1.31 (0.72, 2.38) 0.37
Histology         
   Ductal 49 27.5 56 31.5 73 41.0 Ref  
   Lobular 18 40.9 14 31.8 12 27.3 0.45 (0.20, 1.03) 0.06
   Mixed 11 30.6 17 47.2 8 22.2 0.47 (0.17, 1.27) 0.13
   Other 10 43.5 3 13.0 10 43.5 0.79 (0.30, 2.07) 0.62
Tumor grade         
   Well differentiated 25 36.2 19 27.5 25 36.2 Ref  
   Moderately differentiated 43 28.5 54 35.8 54 35.8 1.06 (0.56, 2.13) 0.88
   Poorly differentiated 20 32.8 17 27.9 24 39.3 0.97 (0.42, 2.25) 0.95
ER         
   Negative 14 17.5 27 33.7 39 48.8 Ref  
   Positive 74 36.8 63 31.3 64 31.8 0.34 (0.17, 0.70) 0.003
PR         
   Negative 24 27.9 28 32.6 34 39.5 Ref  
   Positive 64 32.8 62 31.8 69 35.4 0.76 (0.40, 1.43) 0.39
CK5         
   Negative 72 34.6 64 30.8 72 34.6 Ref  
   Positive 16 22.9 24 34.3 30 42.9 1.72 (0.85, 3.49) 0.13
EGFR         
   Negative 79 34.1 78 33.6 75 32.3 Ref  
   Positive 9 19.1 10 21.3 28 59.6 2.78 (1.21, 6.39) 0.02
  1. *Number of acini reflects averaged values from TDLUs per case in tertiles from lowest to highest; Number of acini per TDLU (1: 0 to 10, 2: 11 to 20, 3: 21 to 30, 4: 31 to 50, 5: 51 to 100, 6: > 100), low = 1 to 1.34; middle = 1.34 to 1.8; high = > 1.8. **P-values, ORs and 95% CIs were obtained from logistic regression analyses comparing cases with the highest to the lowest tertile of number of acini per TDLU adjusted for age and study site.