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Table 3 Genes of known interest in breast cancer

From: Characterization of adjacent breast tumors using oligonucleotide microarrays

 

Tumor

Gene

5A/5B

5A/7

5A/9

ER

NC

D(12.7)

NC

PR

NC

NC

I(2.7)

Androgen receptor

NC

NC

D(2.5)

Epidermal growth factor receptor

NC

NC

NC

ERBB2

NC

NC

NC

VEGF

NC

I(2.0)

D(2.2)

TP53

NC

NC

NC

Ataxia telangiectasia (ATM)

NC

NC

NC

FHIT

NC

NC

NC

BRCA2

NC

NC

NC

RAD50

NC

NC

NC

BARD-1

NC

D(2.9)

D(3.5)

Retinoblastoma-1 (RB1)

NC

NC

NC

Amplified in breast cancer (AIB1)

NC

NC

NC

Breast cancer transcription

NC

NC

NC

   factor (ZaBCl)

   

Thymidylate synthetase

NC

D(3.0)

NC

Multidrug resistance gene (MDR-1)

NC

NC

NC

Thrombospondin-1

NC

NC

D(2.2)

KI-67 antigen

NC

NC

NC

Breast epithelial antigen (BA46)

NC

I(4.3)

NC

Human mammaglobin

NC

I(3.6)

I(36.9)

Human mammaglobin β precursor

I(40.1)

NC

I(29.1)

  1. In addition to several known cancer genes, this list was derived by quering the AffymetrixEASI database for genes on the U95A, using 'breast' as the search term. D(x), an x-fold decrease in gene expression in this tumor compared with tumor 5A; I(x), an x-fold increase in gene expression in this tumor compared to tumor 5A; NC, no change in gene expression in this tumor compared with tumor 5A.