Amplification and high-level expression of heat shock protein 90 marks aggressive phenotypes of human epidermal growth factor receptor 2 negative breast cancer

Table 2 Prognosis of HSP90AA1 and HSP90AB1 in different subtypes of breast cancer.

Subtype	Gene	Cox-regression analysis		Kaplan-Meier survival analysis					COXPH survival analysis
				High 25% vs. others		High 10% vs. others			High 10% vs. others
		P-value	n	P-value	HR(95%CI)	P-value	HR(95%CI)	n	P-value	P-adjusted	n
All samples	HSP90AA1	0.0020	395	0.0499	1.75(1.00-3.06)	0.0241	2.81 (1.15-6.90)	395	0.0193	0.3320	225
(dss)	HSP90AB1	0.0136		0.0404	1.72(1.02-2.90)	0.0011	3.69 (1.68-8.07)		0.0022	0.0008
All samples	HSP90AA1	0.0081	1072	0.0384	1.39(1.02-1.89)	0.0002	2.55(1.55-4.21)	1072	0.0048	0.1069	421
(os)	HSP90AB1	0.0175		0.0401	1.36(1.01-1.83)	0.0024	2.06(1.29-3.28)		0.0010	0.0022
HER2+	HSP90AA1	0.7459	194	0.694	0.89(0.50-1.60)	0.1523	2.07(0.76-5.61)	194	0.4364	0.2703	63
(os)	HSP90AB1	0.5693		0.6728	1.15(0.59-2.24)	0.3733	1.76(0.51-6.13)		4.90E-08	0.1839
HER2-ER+	HSP90AA1	0.1057	506	0.0706	1.52(0.97-2.39)	0.0563	1.92(0.98-3.75)	506	0.1593	0.5829	228
(os)	HSP90AB1	0.0015		0.0918	1.44(0.94-2.20)	0.0005	3.04 (1.63-5.68)		1.53E-05	0.0004
TNBC	HSP90AA1	0.0049	282	0.0302	2.07(1.07-3.98)	< 0.0001	16.9(4.66-60.9)	282	0.0079	0.0394	105
(os)	HSP90AB1	0.1328		0.0483	1.82(1.00-3.30)	0.2936	1.83 0.59-5.66)		0.4344	0.9968

Cox-regression survival analysis was performed using gene expression signal as continuing variable. CI, confidence interval; Dss, disease specific survival (death from breast cancer); HR, Hazard Ratio; n: number of samples; os, over-all survival.

ISSN: 1465-542X