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Figure 2 | Breast Cancer Research

Figure 2

From: Amplification and high-level expression of heat shock protein 90 marks aggressive phenotypes of human epidermal growth factor receptor 2 negative breast cancer

Figure 2

Correlation of HSP90 expression and coding region copy number aberrations. (A) Genome scans for poor prognosis associated gene. Correlation between gene expression and risk of death from breast cancer was assessed using Cox-regression survival analyses. Direct correlation is high-level expression was associated with poor survival. Inverse correlation is high-level expression was associated with better outcome. The y axis represents the level of significance for each expression probe set (log-transformed P values) at the relative genomic position on each chromosome along the x axis from the short-arm terminus (left) to the long-arm terminus (right). Bottom panel shows somatic CNA distribution across entire genome. (B) Genome scans for somatic CNA distribution and its correlation with HSP90 and HSF1 expression. Upper panel shows percentage of amplification (low-level and high-level amplification) and deletion (homozygous and hemizygous deletion) at each detected chromosome region in a group of 481 breast cancer patients. Bottom panel shows correlation between CNA and HSP90 and HSF1 mRNA expression. ERBB2 was used as positive control. Analysis of variance (ANOVA) was performed to test for association between copy numbers and gene expression. (C) Scatterplots of correlation between mRNA expression and copy numbers of select genes: homozygous deletion (0), hemizygous deletion (1), normal copy number (2), low level amplification (3) and high level amplification (≥4), measured by ANOVA analysis. Circles represent average levels. Vertical bars represent 0.95 confidence intervals.

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