Variants in the vitamin D pathway, serum levels of vitamin D, and estrogen receptor negative breast cancer among African-American women: a case-control study

Table 4 Changes in risk of estrogen receptor-negative breast cancer by race with inclusion of single-nucleotide polymorphisms in CYP24A1

Model	Variable	Adjusted OR (95% CI)	Pvalue
Base model	Race (AA versus EA)	1.53 (1.06-2.22)	0.02
Base model + SNPs	Race (AA versus EA)	1.20 (0.80-1.79)	0.38
	rs2209314 (AG/GG versus AA)	0.57 (0.36-0.89)	0.01
	rs2762941 (AG versus AA)	1.47 (0.96-2.25)	0.04
	rs2762941 (GG versus AA)	1.88 (1.15-3.06)

Covariates included in the base model were age at diagnosis, body mass index, family history of breast cancer, education, and race. Odds ratio (OR) and 95% confidence interval (CI) for race after adjustment for other covariates are shown. Based on this model, seven single-nucleotide polymorphisms (SNPs) in CYP24A1 (rs927650, rs1570669, rs2209314, rs3787555, rs2762941, rs4809959, and rs2585428) and one SNP in VDR (rs3819545) that were associated with estrogen receptor-negative (ER^-) breast cancer risk in either African-American (AA) or European-American (EA) women were entered and backward-selected. Two SNPs, rs2209314 and rs2762941, remained in the final model with a P value of less than 0.05. ORs and 95% CIs for race and the two SNPs are shown.

ISSN: 1465-542X