|
Model
|
Variable
|
Adjusted OR (95% CI)
|
Pvalue
|
|---|
|
Base model
|
Race (AA versus EA)
|
1.53 (1.06-2.22)
|
0.02
|
|
Base model + SNPs
|
Race (AA versus EA)
|
1.20 (0.80-1.79)
|
0.38
|
| |
rs2209314 (AG/GG versus AA)
|
0.57 (0.36-0.89)
|
0.01
|
| |
rs2762941 (AG versus AA)
|
1.47 (0.96-2.25)
|
0.04
|
| |
rs2762941 (GG versus AA)
|
1.88 (1.15-3.06)
| |
- Covariates included in the base model were age at diagnosis, body mass index, family history of breast cancer, education, and race. Odds ratio (OR) and 95% confidence interval (CI) for race after adjustment for other covariates are shown. Based on this model, seven single-nucleotide polymorphisms (SNPs) in CYP24A1 (rs927650, rs1570669, rs2209314, rs3787555, rs2762941, rs4809959, and rs2585428) and one SNP in VDR (rs3819545) that were associated with estrogen receptor-negative (ER-) breast cancer risk in either African-American (AA) or European-American (EA) women were entered and backward-selected. Two SNPs, rs2209314 and rs2762941, remained in the final model with a P value of less than 0.05. ORs and 95% CIs for race and the two SNPs are shown.
