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Table 3 Single-nucleotide polymorphisms in VDR and CYP24A1 and differential association with estrogen receptor-specific breast cancer risk among African-American and European-American women

From: Variants in the vitamin D pathway, serum levels of vitamin D, and estrogen receptor negative breast cancer among African-American women: a case-control study

    African-American European-American  
Gene SNP Genotype Cases/Controls OR (95% CI) P trend Cases/Controls OR (95% CI) P trend P interaction
VDR rs10783218 GG 178/304 1.00 0.82 194/352 1.00 0.04 0.04
   GA/AA 85/150 0.96 (0.69-1.34)   20/17 2.05 (1.02-4.12)   
VDR rs3819545 AA 71/242 1.00 0.04 22/162 1.00 0.38 0.04
   AG 45/168 0.91 (0.59-1.40)   26/156 1.22 (0.66-2.26)   
   GG 3/43 0.23 (0.07-0.77)   11/52 1.40 (0.62-3.15)   
CYP24A1 rs927650 GG 66/258 1.00 0.62 10/116 1.00 0.003 0.10
   GA 47/170 1.09 (0.71-1.68)   29/186 1.76 (0.81-3.78)   
   AA 8/27 1.18 (0.50-2.79)   20/68 3.46 (1.50-7.96)   
CYP24A1 rs1570669 GG 15/81 1.00 0.69 32/158 1.00 0.03 0.05
   GA 69/219 1.77 (0.94-3.31)   24/162 0.71 (0.40-1.27)   
   AA 37/154 1.36 (0.69-2.67)   3/50 0.28 (0.08-0.97)   
CYP24A1 rs2209314 AA 102/393 1.00 0.33 46/208 1.00 0.004 0.003
   AG/GG 19/61 1.34 (0.74-2.40)   13/162 0.38 (0.20-0.73)   
CYP24A1 rs3787555 CC 79/326 1.00 0.02 25/175 1.00 0.91 0.09
   CA 37/122 1.42 (0.90-2.24)   29/155 1.25 (0.69-2.24)   
   AA 5/7 3.79 (1.11-12.91)   5/38 0.83 (0.30-2.35)   
CYP24A1 rs2762941 AA 16/120 1.00 0.004 24/132 1.00 0.54 0.05
   AG 61/212 1.97 (1.07-3.61)   26/168 0.89 (0.49-1.65)   
   GG 44/122 2.62 (1.38-4.98)   9/68 0.78 (0.34-1.78)   
CYP24A1 rs4809959 GG 32/133 1.00 0.99 14/131 1.00 0.01 0.07
   GA 64/223 1.13 (0.70-1.83)   26/172 1.43 (0.71-2.88)   
   AA 25/98 0.98 (0.54-1.78)   19/66 2.71 (1.25-5.86)   
CYP24A1 rs2585428 GG 27/109 1.00 0.65 26/90 1.00 0.006 0.02
   GA 66/246 1.12 (0.67-1.87)   22/175 0.46 (0.24-0.87)   
   AA 28/100 1.15 (0.63-2.10)   11/105 0.36 (0.17-0.79)   
  1. Odds ratio (OR) and 95% confidence interval (CI) are adjusted for covariates, including age, proportion of European ancestry, body mass index, family history of breast cancer, and education. Ptrend was for genetic dose response by coding genotypes as 0, 1, and 2 on the basis of the number of variant alleles. Pinteraction was for the differences in ORs between African-American and European-American women, and a Pinteraction of less than 0.10 was deemed significant. SNP, single-nucleotide polymorphism.
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