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Table 3 Single-nucleotide polymorphisms in VDR and CYP24A1 and differential association with estrogen receptor-specific breast cancer risk among African-American and European-American women

From: Variants in the vitamin D pathway, serum levels of vitamin D, and estrogen receptor negative breast cancer among African-American women: a case-control study

   

African-American

European-American

 

Gene

SNP

Genotype

Cases/Controls

OR (95% CI)

P trend

Cases/Controls

OR (95% CI)

P trend

P interaction

VDR

rs10783218

GG

178/304

1.00

0.82

194/352

1.00

0.04

0.04

  

GA/AA

85/150

0.96 (0.69-1.34)

 

20/17

2.05 (1.02-4.12)

  

VDR

rs3819545

AA

71/242

1.00

0.04

22/162

1.00

0.38

0.04

  

AG

45/168

0.91 (0.59-1.40)

 

26/156

1.22 (0.66-2.26)

  
  

GG

3/43

0.23 (0.07-0.77)

 

11/52

1.40 (0.62-3.15)

  

CYP24A1

rs927650

GG

66/258

1.00

0.62

10/116

1.00

0.003

0.10

  

GA

47/170

1.09 (0.71-1.68)

 

29/186

1.76 (0.81-3.78)

  
  

AA

8/27

1.18 (0.50-2.79)

 

20/68

3.46 (1.50-7.96)

  

CYP24A1

rs1570669

GG

15/81

1.00

0.69

32/158

1.00

0.03

0.05

  

GA

69/219

1.77 (0.94-3.31)

 

24/162

0.71 (0.40-1.27)

  
  

AA

37/154

1.36 (0.69-2.67)

 

3/50

0.28 (0.08-0.97)

  

CYP24A1

rs2209314

AA

102/393

1.00

0.33

46/208

1.00

0.004

0.003

  

AG/GG

19/61

1.34 (0.74-2.40)

 

13/162

0.38 (0.20-0.73)

  

CYP24A1

rs3787555

CC

79/326

1.00

0.02

25/175

1.00

0.91

0.09

  

CA

37/122

1.42 (0.90-2.24)

 

29/155

1.25 (0.69-2.24)

  
  

AA

5/7

3.79 (1.11-12.91)

 

5/38

0.83 (0.30-2.35)

  

CYP24A1

rs2762941

AA

16/120

1.00

0.004

24/132

1.00

0.54

0.05

  

AG

61/212

1.97 (1.07-3.61)

 

26/168

0.89 (0.49-1.65)

  
  

GG

44/122

2.62 (1.38-4.98)

 

9/68

0.78 (0.34-1.78)

  

CYP24A1

rs4809959

GG

32/133

1.00

0.99

14/131

1.00

0.01

0.07

  

GA

64/223

1.13 (0.70-1.83)

 

26/172

1.43 (0.71-2.88)

  
  

AA

25/98

0.98 (0.54-1.78)

 

19/66

2.71 (1.25-5.86)

  

CYP24A1

rs2585428

GG

27/109

1.00

0.65

26/90

1.00

0.006

0.02

  

GA

66/246

1.12 (0.67-1.87)

 

22/175

0.46 (0.24-0.87)

  
  

AA

28/100

1.15 (0.63-2.10)

 

11/105

0.36 (0.17-0.79)

  
  1. Odds ratio (OR) and 95% confidence interval (CI) are adjusted for covariates, including age, proportion of European ancestry, body mass index, family history of breast cancer, and education. Ptrend was for genetic dose response by coding genotypes as 0, 1, and 2 on the basis of the number of variant alleles. Pinteraction was for the differences in ORs between African-American and European-American women, and a Pinteraction of less than 0.10 was deemed significant. SNP, single-nucleotide polymorphism.
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Breast Cancer Research

ISSN: 1465-542X

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