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Table 2 Single-nucleotide polymorphisms in VDR and CYP24A1 and differential associations with breast cancer risk between African-American and European-American women in the Women's Circle of Health Study

From: Variants in the vitamin D pathway, serum levels of vitamin D, and estrogen receptor negative breast cancer among African-American women: a case-control study

   

African-American

European-American

 

Gene

SNP

Genotype

Cases/Controls

Adjusted OR

(95% CI)

P trend

Cases/Controls

Adjusted OR

(95% CI)

P trend

P interaction

VDR

rs11608702

AA

330/261

1.00

0.37

166/190

1.00

0.02

0.01

  

AT

175/175

0.80 (0.61-1.04)

 

160/159

1.15 (0.84-1.58)

  
  

TT

37/25

1.13 (0.65-1.95)

 

55/31

1.88 (1.14-3.09)

  

VDR

rs12721364

GG

520/420

1.00

0.01

303/298

1.00

0.90

0.02

  

GA/AA

24/40

0.53 (0.31-0.90)

 

78/82

0.98 (0.68-1.41)

  

VDR

rs2239186

AA

497/393

1.00

0.001a

265/256

1.00

0.46

0.01

  

AG/GG

47/68

0.53 (0.35-0.79)

 

115/125

0.85 (0.62-1.17)

  

VDR

rs11568820 (Cdx2)

GG

18/26

1.00

0.04

234/232

1.00

0.68

0.04

  

GA

143/140

1.55 (0.79-3.03)

 

129/132

0.99 (0.72-1.36)

  
  

AA

384/295

1.94 (1.01-3.74)

 

18/18

0.83 (0.39-1.75)

  

CYP24A1

rs912505

AA

173/139

1.00

0.71

236/216

1.00

0.02

0.05

  

AG

268/244

0.89 (0.66-1.19)

 

132/139

0.80 (0.59-1.10)

  
  

GG

104/77

1.14 (0.78-1.66)

 

13/27

0.36 (0.17-0.76)

  

CYP24A1

rs3787555

CC

379/331

1.00

0.14

206/183

1.00

0.03

0.02

  

CA

154/123

1.17 (0.88-1.56)

 

149/155

0.81 (0.59-1.10)

  
  

AA

14/7

1.88 (0.73-4.83)

 

25/41

0.50 (0.28-0.89)

  
  1. Odds ratio (OR) and 95% confidence interval (CI) are adjusted for covariates, including age, proportion of European ancestry, body mass index, family history of breast cancer, and education. Ptrend was for genetic dose response by coding genotypes as 0, 1, and 2 on the basis of the number of variant alleles. Pinteraction was for the differences in ORs between African-American and European-American women, and a Pinteraction of less than 0.10 was deemed significant. aSingle-nucleotide polymorphism (SNP) rs2239186 in VDR remained significant after correction for multiple comparison by permutation.
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Breast Cancer Research

ISSN: 1465-542X

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