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Table 2 Single-nucleotide polymorphisms in VDR and CYP24A1 and differential associations with breast cancer risk between African-American and European-American women in the Women's Circle of Health Study

From: Variants in the vitamin D pathway, serum levels of vitamin D, and estrogen receptor negative breast cancer among African-American women: a case-control study

    African-American European-American  
Gene SNP Genotype Cases/Controls Adjusted OR
(95% CI)
P trend Cases/Controls Adjusted OR
(95% CI)
P trend P interaction
VDR rs11608702 AA 330/261 1.00 0.37 166/190 1.00 0.02 0.01
   AT 175/175 0.80 (0.61-1.04)   160/159 1.15 (0.84-1.58)   
   TT 37/25 1.13 (0.65-1.95)   55/31 1.88 (1.14-3.09)   
VDR rs12721364 GG 520/420 1.00 0.01 303/298 1.00 0.90 0.02
   GA/AA 24/40 0.53 (0.31-0.90)   78/82 0.98 (0.68-1.41)   
VDR rs2239186 AA 497/393 1.00 0.001a 265/256 1.00 0.46 0.01
   AG/GG 47/68 0.53 (0.35-0.79)   115/125 0.85 (0.62-1.17)   
VDR rs11568820 (Cdx2) GG 18/26 1.00 0.04 234/232 1.00 0.68 0.04
   GA 143/140 1.55 (0.79-3.03)   129/132 0.99 (0.72-1.36)   
   AA 384/295 1.94 (1.01-3.74)   18/18 0.83 (0.39-1.75)   
CYP24A1 rs912505 AA 173/139 1.00 0.71 236/216 1.00 0.02 0.05
   AG 268/244 0.89 (0.66-1.19)   132/139 0.80 (0.59-1.10)   
   GG 104/77 1.14 (0.78-1.66)   13/27 0.36 (0.17-0.76)   
CYP24A1 rs3787555 CC 379/331 1.00 0.14 206/183 1.00 0.03 0.02
   CA 154/123 1.17 (0.88-1.56)   149/155 0.81 (0.59-1.10)   
   AA 14/7 1.88 (0.73-4.83)   25/41 0.50 (0.28-0.89)   
  1. Odds ratio (OR) and 95% confidence interval (CI) are adjusted for covariates, including age, proportion of European ancestry, body mass index, family history of breast cancer, and education. Ptrend was for genetic dose response by coding genotypes as 0, 1, and 2 on the basis of the number of variant alleles. Pinteraction was for the differences in ORs between African-American and European-American women, and a Pinteraction of less than 0.10 was deemed significant. aSingle-nucleotide polymorphism (SNP) rs2239186 in VDR remained significant after correction for multiple comparison by permutation.