Recurrence risk over time based on the expression of Ki67 and cyclin D
. (a) Expression of Ki67 increased with increasing percentage of cyclin D1-positive nuclei in the breast tumours. (b) Kaplan-Meier plot showing that the combination of high Ki67 and low cyclin D1 expression was associated with high risk of recurrence (green). Patients exhibiting a high fraction of cyclin D1-positive tumour cell nuclei in concurrence with low Ki67 expression showed the lowest risk of recurrence (red).