Forest plot showing the effect of CCND1 amplification, cytoplasmic and nuclear cyclin D
expression. (a) Amplified against nonamplified breast cancers in the subgroups of treatment, nodal status and Ki67. (b) High cytoplasmic intensity against low or intermediate intensity. (c) Nuclear fraction of 1 to 100% against < 1% positive nuclei. Reference population for all subgroups was nonamplified patients (except for amplification status). HR, hazard ratio; neg, negative; pos, positive.