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Table 2 Frequencies and P values for AI at chromosome 10q in primary breast tumors and metastases

From: Relevance of PTEN loss in brain metastasis formation in breast cancer patients

  Brain metastases (n= 21) All primary tumors (n= 77)a Primary tumors without relapse (n= 39) Primary tumors with brain relapse (n= 10) Primary tumors with other relapse (n= 17)
  n % n % Pvalueb n % Pvalueb n % Pvalueb n % Pvalueb
PTEN (CR1) c 11 52.4 18 23.4 0.006 7 17.9 0.003 5 50.0 n.s. 2 11.8 0.006
CR2 c 10 47.6 22 28.6 n.s. 11 28.2 n.s. 5 50.0 n.s. 3 17.6 n.s.
all AI 13 61.9 29 37.7 n.s. 13 33.3 0.055 5 50.0 n.s. 5 29.4 n.s.
normal 8 38.1 48 62.3 - 26 66.7 - 5 50.0 - 12 70.6 -
  1. aRelapse pattern not recorded for 11 patients. bP values calculated with the Fisher Exact test (brain metastases versus other groups). cCR1 and CR2 are included in all AI. AI, allelic imbalance; CR2, core region 2; allelic imbalance around markers D10S190 and D10S1236; n.s., not significant; PTEN (CR1), core region 1 allelic imbalance around markers D10S1765 and D10S541.