Skip to main content

Advertisement

Springer Nature is making Coronavirus research free. View research | View latest news | Sign up for updates

Table 1 Statistically significantly different regions between primary breast tumors and brain metastases

From: Relevance of PTEN loss in brain metastasis formation in breast cancer patients

Chrom. regiona bp start bp end Size (Mbp) % del PT % gain PT % del MET % gain MET Pvalue Fdr
1 p22.1-21.2 94472000 101828000 7.4 25.8 3.2 0.0 20.0 0.005 0.04
7 p22.1-15.2 5383000 27787000 22.4 3.2-12.9 12.9 0.0 70.0-80.0 0.001-0.002 0.01-0.02
  p11.2 54565000 55475001 0.5 0.0 9.7-12.9 0.0 70.0 0.001-0.003 0.01-0.02
10 pter-p12.1 173000 28895000 28.7 0.0 0.0 20.0 40.0 0.005 0.04
  q11.22-q21.1 49685000 59935000 10.3 3.2 6.5 60.0 20.0 0.005 0.04
  q22.1-qter 71226000 134848000 63.6 0-12.9 3.2-6.5 60.0-90.0 0.0-10.0 0.001-0.002 0.02
11 pter-p15.4 188000 9693000 9.5 12.9-19.4 9.7-12.9 70.0 0.0 0.001-0.005 0.01-0.04
16 q24.2 87416000 87465000 0.0 87.1 0.0 30.0 0.0 0.002 0.02
17 q11.2 26591000 29500000 2.9 16.1-22.6 25.8-29.0 70.0 0.0 0.001-0.005 0.01-0.04
  1. fdr, false discovery rate; MET, brain metastasis; PT, primary tumor. aThe complete region that was statistically significantly different between the two groups (primary versus metastasis). Therefore, some break points in some patients might occur within the region, causing a variation in the frequencies of deletions/amplifications within a region and P values and fdr.