CD8+ lymphocyte infiltration is an independent favorable prognostic indicator in basal-like breast cancer

Breast Cancer Research

Table 4 Hazards for breast cancer-specific survival with multivariate analysis in TNP, core basal, and 5NP groups

Variable	TNP (n= 496)		Core basal (n= 287)		5NP (n= 130)
	HR	P	HR	P	HR	P
Age	0.90		0.91		1.07
≥ 50 vs. < 50 years	(0.66-1.22)	0.488	(0.62-1.35)	0.648	(0.54-2.14)	0.830
Grade	1.74		1.54		1.81
3 vs. 1 and 2	(1.11-2.70)	0.015	(0.80-2.97)	0.201	(0.74-4.41)	0.191
Tumor size	1.66		1.85		1.49
> 2 vs. ≤ 2 cm	(1.19-2.30)	0.003	(1.23-2.79)	0.003	(0.71-3.12)	0.293
Nodal status	2.00		2.16		1.58
Positive vs. negative	(1.42-2.83)	< 0.001	(1.39-3.35)	0.001	(0.73-3.42)	0.244
Lymphovascular invasion	1.55		1.52		3.13
Positive vs. negative	(1.08-2.21)	0.017	(0.97-2.36)	0.065	(1.27-7.77)	0.013
iTIL	0.48		0.35		0.99
≥ 1 vs. 0	(0.34-0.67)	< 0.001	(0.23-0.54)	< 0.001	(0.48-2.04)	0.986

5NP, five negative phenotype; HR, hazard ratio; iTIL, intratumoral tumor-infiltrating lymphocyte; TNP, triple-negative phenotype.

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