Variable | Univariate analysis | Multivariate analysis n= 3,144 | ||
---|---|---|---|---|
 | HR (95% CI) | Pvalue | HR (95% CI) | Pvalue |
Age | Â | Â | Â | Â |
≥ 50 vs. < 50 years | 0.85 (0.75-0.96) | 0.011 | 1.01 (0.88-1.16) | 0.884 |
Grade | Â | Â | Â | Â |
3 vs. 1 and 2 | 2.12 (1.87-2.41) | < 0.001 | 1.57 (1.35-1.82) | < 0.001 |
Tumor size | Â | Â | Â | Â |
> 2 vs. ≤ 2 cm | 2.17 (1.92-2.45) | < 0.001 | 1.59 (1.36-1.83) | < 0.001 |
Nodal status | Â | Â | Â | Â |
Positive vs. negative | 2.79 (2.48-3.15) | < 0.001 | 2.05 (1.76-2.39) | < 0.001 |
Lymphovascular invasion | Â | Â | Â | Â |
Positive vs. negative | 2.25 (1.99-2.54) | < 0.001 | 1.29 (1.10-1.51) | 0.001 |
Subtype | Â | Â | Â | |
Luminal B vs. luminal A | 2.08 (1.78-2.45) | < 0.001 | 1.75 (1.46-2.09) | < 0.001 |
HER2+/ER- vs. luminal A | 2.98 (2.40-3.70) | < 0.001 | 2.51 (2.99-3.19) | < 0.001 |
Core basal vs. luminal A | 2.30 (1.87-2.84) | < 0.001 | 2.02 (1.58-2.58) | < 0.001 |
5NP vs. luminal A | 1.65 (1.30-2.10) | 0.002 | 1.49 (1.12-1.97) | 0.011 |
iTIL | Â | Â | Â | Â |
≥ 1 vs. 0 | 1.02 (0.89-1.17) | 0.761 | 0.79 (0.68-0.91) | < 0.001 |