Table 2 Hazards for breast cancer-specific survival in the whole cohort with univariate and multivariate analyses

Age

≥ 50 vs. < 50 years

0.85 (0.75-0.96)

0.011

1.01 (0.88-1.16)

0.884

Grade

3 vs. 1 and 2

2.12 (1.87-2.41)

< 0.001

1.57 (1.35-1.82)

< 0.001

Tumor size

> 2 vs. ≤ 2 cm

2.17 (1.92-2.45)

< 0.001

1.59 (1.36-1.83)

< 0.001

Nodal status

Positive vs. negative

2.79 (2.48-3.15)

< 0.001

2.05 (1.76-2.39)

< 0.001

Lymphovascular invasion

Positive vs. negative

2.25 (1.99-2.54)

< 0.001

1.29 (1.10-1.51)

0.001

Subtype

Luminal B vs. luminal A

2.08 (1.78-2.45)

< 0.001

1.75 (1.46-2.09)

< 0.001

HER2⁺/ER^- vs. luminal A

2.98 (2.40-3.70)

< 0.001

2.51 (2.99-3.19)

< 0.001

Core basal vs. luminal A

2.30 (1.87-2.84)

< 0.001

2.02 (1.58-2.58)

< 0.001

5NP vs. luminal A

1.65 (1.30-2.10)

0.002

1.49 (1.12-1.97)

0.011

iTIL

≥ 1 vs. 0

1.02 (0.89-1.17)

0.761

0.79 (0.68-0.91)

< 0.001