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Table 4 Correlation between alterations in TP53/CHEK2/ATM ("hit") and in vivo resistance to doxorubicin/FUMI

From: Low expression levels of ATM may substitute for CHEK2 /TP53 mutations predicting resistance towards anthracycline and mitomycin chemotherapy in breast cancer

 

Hit

Non-Hit

Progressive disease

141

42

Responders

233

284

  

P = 0.0267

  1. Cohort 1 (Dox/Fumi)
  2. 1 Patients lacking response to therapy/with mutations in TP53 (L2/L3) or CHEK2 or low expression of ATM (lower 20% percentile of cohort)
  3. 2 Patients lacking response to therapy/without mutations in TP53 (L2/L3) or CHEK2 low expression of ATM (lower 20% percentile of cohort)
  4. 3 Patients with response to therapy (SD, PR or CR)/with mutations in TP53 (L2/L3) or CHEK2 or low expression of ATM (lower 20% percentile of cohort)
  5. 4 Patients with response to therapy (SD, PR or CR)/without mutations in TP53 (L2/L3) or CHEK2 or low expression of ATM (lower 20% percentile of cohort)
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Breast Cancer Research

ISSN: 1465-542X

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