Figure 6
Regulation of actin cytoskeleton in the tamoxifen resistant cell line, MCF-7-TamR. The pathway illustrates changes to proteins expression, TamR cell line vs. control, involved in regulating the actin cytoskeleton. All red proteins are significantly up-regulated and all blue proteins are significantly down-regulated. The ratio value for each significantly regulated protein is indicated to the right. Solid lines with no arrow indicate physical interaction. Solid lines with an arrow or bar at the end indicate direct activation or inhibition, respectively. Dotted lines indicate indirect or unknown method of interaction. The orange lines highlight the Rho activation pathways and the green lines highlight integrin mediated focal adhesions.