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Figure 1 | Breast Cancer Research

Figure 1

From: New tricks for metastasis-associated macrophages

Figure 1

Macrophages provide survival signals to metastatic tumor cells. VCAM-1 expressed upon metastatic tumor cells engages α4β1 or α4β7 integrins on metastasis-associated macrophages. This engagement results in VCAM-1 clustering that confers a survival signal to the tumor cell and thereby its establishment in the metastatic site. VCAM-1, vascular cell adhesion molecule-1.

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