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Table 1 Targeted therapies and their main targets

From: Targeted therapies in breast cancer: are heart and vessels also being targeted?

Drug

Targets

Trastuzumab

HER2 (epitope IV)

Lapatinib

EGFR and HER2

Pertuzumab

HER2 (epitope II)

Neratinib

EGFR, HER2, HER4 (irreversible)

T-DM1

HER2

Tanespimycin

HSP-90

BIBW 2992

EGFR, HER2

Gefitinib

EGFR

Erlotinib

EGFR

Cetuximab

EGFR

Bevacizumab

VEGF-A

Sunitinibª

VEGFR2, PDGFR-beta, c-kit, FLT3

Sorafenibª

VEGFR-2/PDGFR-beta, RAF kinase

Pazopanib

VEGFR-1, VEGFR-2, VEGFR-3, cKIT, PDGFR

Vandetanib

VEGFR2, EGFR, RET

  1. ªTargeted therapies with low specificity and blockade of additional targets. EGFR, epidermal growth factor receptor; HER, human epidermal growth factor receptor; PDGFR, platelet-derived growth factor receptor; T-DM1, trastuzumab-DM1; VEGF, vascular endothelial growth factor ; VEGFR, vascular endothelial growth factor receptor.
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Breast Cancer Research

ISSN: 1465-542X

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