Skip to main content

Advertisement

Table 1 Targeted therapies and their main targets

From: Targeted therapies in breast cancer: are heart and vessels also being targeted?

Drug Targets
Trastuzumab HER2 (epitope IV)
Lapatinib EGFR and HER2
Pertuzumab HER2 (epitope II)
Neratinib EGFR, HER2, HER4 (irreversible)
T-DM1 HER2
Tanespimycin HSP-90
BIBW 2992 EGFR, HER2
Gefitinib EGFR
Erlotinib EGFR
Cetuximab EGFR
Bevacizumab VEGF-A
Sunitinibª VEGFR2, PDGFR-beta, c-kit, FLT3
Sorafenibª VEGFR-2/PDGFR-beta, RAF kinase
Pazopanib VEGFR-1, VEGFR-2, VEGFR-3, cKIT, PDGFR
Vandetanib VEGFR2, EGFR, RET
  1. ªTargeted therapies with low specificity and blockade of additional targets. EGFR, epidermal growth factor receptor; HER, human epidermal growth factor receptor; PDGFR, platelet-derived growth factor receptor; T-DM1, trastuzumab-DM1; VEGF, vascular endothelial growth factor ; VEGFR, vascular endothelial growth factor receptor.