Insulin-like growth factor-1, insulin-like growth factor binding protein-3 and lobule type in the Nurses' Health Study II

Table 4 Predominant type 1/no type 3 lobules according to batch-specific quartiles of plasma IGFBP-3

	IGFBP-3 (ng/ml)
	Quartile 1	Quartile 2	Quartile 3	Quartile 4	P value
Predominant type 1, no type 3/other lobule type (n)	(22/95)	(19/99)	(17/101)	(16/103)
Age and batch-adjusted^a	1 (reference)	0.83 (0.40 to 1.70)	0.75 (0.36 to 1.57)	0.71 (0.33 to 1.51)	0.48
Multivariate model 1^b	1 (reference)	0.95 (0.45 to 1.99)	0.83 (0.39 to 1.78)	0.67 (0.31 to 1.45)	0.47
Multivariate model 2^c	1 (reference)	0.87 (0.41 to 1.87)	0.84 (0.39 to 1.83)	0.61 (0.28 to 1.35)	0.39
Multivariate model 3^d	1 (reference)	1.06 (0.48 to 2.37)	1.17 (0.48 to 2.81)	0.93 (0.36 to 2.41)	0.63

Data (vs. other types) from the Nurses' Health Study II presented as odds ratio (95% confidence interval) unless stated otherwise. ^aAge at biopsy (continuous), insulin-like growth factor binding protein-3 (IGFBP-3) batch. ^bAge at biopsy (continuous), IGFBP-3 batch, body mass index (continuous), menopausal status (premenopausal/dubious; postmenopausal, no postmenopausal hormone use; postmenopausal, postmenopausal hormone use), histological category of benign breast disease (proliferative without atypia, proliferative with atypia). ^cMultivariate model 1 plus parity (nulliparous, parous), alcohol (none, < 1.5, 1.5 to 4.5, 4.5+ g/day). ^dMultivariate model 2 plus square-root transformed insulin-like growth factor 1 (continuous).

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