Figure 1
From: Challenges and opportunities in the targeting of fibroblast growth factor receptors in breast cancer
Alterations in the FGFR signalling pathway that influence breast cancer. Single nucleotide polymorphisms (SNPs) influence breast cancer risk (FGFR2), and prognosis in established cancers likely through effects on motility and invasive capacity (FGFR4). Somatic alterations presenting potential therapeutic targets include amplification of FGFR1 and FGFR2, and aberrant FGF2 ligand expressed in a paracrine or autocrine fashion.