Immunohistochemical detection of Polo-like kinase-1 (PLK1) in primary breast cancer is associated with TP53mutation and poor clinical outcome

Table 1 Clinico-pathological characteristics of the patients and the odds ratios

Parameter		PLK1	Staining	P-value	Odds Ratio
		Pos (N(%))	Neg (N(%))
N		23 (10.7)	192 (89.3)	-	-
P53 mutational status	mutant	12 (5.6)	46 (21.4)	0.0063	3.46
	wild type	11 (5.1)	146 (67.9)
	unknown	0	0
Histological Grade	1 to 2	2 (1.0)	108 (51.2)	< 0.001	14.18
	3	21 (10.0)	80 (37.9)
	unknown	0	4
Survival	dead	9 (4.2)	37 (15.8)	0.02 (Log Rank)	2.318 (HR)
	alive	14 (6.5)	155 (73.5)
	unknown	0	0
Menopause	pre-peri	8 (3.9)	42 (20.2)	0.1861	1.96
	post	14 (6.7)	144 (69.2)
	unknown	1	6
Lymph Node Status	positive	12 (5.7)	90 (42.7)	0.8257	1.19
	negative	11 (5.2)	98 (46.5)
	unknown	0	4
Size	< 2 cm	17 (7.9)	138 (64.2)	1	1.11
	>/ = 2 cm	6 (2.8)	54 (25.1)
	unknown	0	0
Luminal A	positive	7 (3.3)	99 (47.1)	0.075	0.42
	negative	15 (7.1)	90 (42.4)
	unknown	1	3
Luminal B	positive	2 (1.0)	37 (17.6)	0.382	0.41
	negative	20 (9.5)	152 (71.9)
	unknown	1	3
HER2	positive	5 (2.4)	28 (12.9)	0.344	1.76
	negative	17 (8.1)	162 (76.7)
	unknown	1	2
ER-alpha	positive	12 (5.6)	151 (70.6)	0.0081	3.46
	negative	11 (5.1)	40 (18.7)
	unknown	0	1
PR	positive	10 (4.7)	110 (51.4)	0.266	0.57
	negative	13 (6.1)	81 (37.9)
	unknown	0	1
Triple negative	yes	8 (3.8)	25 (11.9)	0.010	3.8
	no	14 (6.7)	164 (77.6)
	unknown	1	3
MDM2	positive	10 (4.7)	31 (14.5)	0.004	3.95
	negative	13 (6.1)	159 (74.7)
	unknown	0	2
Ki67	positive	9 (4.3)	19 (9.1)	0.0004	6.63
	negative	12 (5.8)	168 (80.8)
	unknown	1	5

The Odds ratio determines the likelihood of showing any given characteristic if the tumour is PLK1 positive as opposed to PLK1 negative. Where numbers in individual categories do not add up to 215 this is due, in part, to loss of TMA spot data (tumour cut out, folded spots, low cellularity) from individual patients. *Luminal stains are based on IHC data and are defined as: luminal A, ER⁺ PR⁺ HER2^- ; and luminal B, ER⁺ PR^- HER2^-

ISSN: 1465-542X