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Table 1 Summary of qualitative 1H-MRS literature published to date

From: In vivo proton magnetic resonance spectroscopy of breast cancer: a review of the literature

Study n Technique Sensitivity Specificity PPV
Roebuck et al. 1998 [3] 17 SV 70% 86% 88%
Gribbestad et al. 1998 [23] 22 SV 50% 100% 100%
Kvistad et al. 1999 [4] 40 SV 82% 61% 82%
Cecil et al. 2001 [24] 38 SV 83% 87% 90%
Yeung et al. 2001 [25] 30 SV 92% 83% 97%
Jagannathan et al. 2001 [5] 46 SV 81% 86% 93%
Kim et al. 2003 [26] 35 SV 100% 100% 100%
Joe et al. 2005 [27] 15 SV 100% NA NA
Stanwell et al. 2005 [28] 64 SV 80% 86% 84%
Jacobs et al. 2005 [18] 9 MRSI 80% 100% 100%
Geraghty et al. 2008 [29] 16 SV 88% NA NA
Baltzer et al. 2011 [30] 62 SV 62% 86% 90%
Chen et al. 2011 [31] 62 SV 73% NA NA
  1. n = number of participants. 1H-MRS, magnetic resonance spectroscopy; MRSI, magnetic resonance spectroscopic imaging; NA, not applicable; PPV, positive predictive value; SV, single-voxel.