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Table 4 Associations between circulating miRNA expression and clinicopathologic variables

From: Expression profiling of cancerous and normal breast tissues identifies microRNAs that are differentially expressed in serum from patients with (metastatic) breast cancer and healthy volunteers

Group Variable Test MIR-215 MIR-299-5p MIR-411 MIR-452
    Result P-value Result P-value Result P-value Result P-value
Clinicopathologic Age Spearman correlation R = -0.184 P = 0.113 R = -0.455 P < 0.001 R = -0.362 P = 0.001 R = -0.052 P = 0.657
  ERa Mann-Whitney U test T = -1.059 P = 0.295 T = 0.658 P = 0.516 T = 0.305 P = 0.763 T = 1.194 P = 0.244
  PRa Mann-Whitney U test T = -0.672 P = 0.504 T = -0.193 P = 0.848 T = -0.645 P = 0.521 T = 1.519 P = 0.136
  HRa Mann-Whitney U test T = -1.233 P = 0.225 T = 0.632 P = 0.534 T = 0.299 P = 0.767 T = 1.015 P = 0.321
  ERBB2a Mann-Whitney U test T = 0.051 P = 0.960 T = -1.237 P = 0.222 T = -1.594 P = 0.120 T = -0.841 P = 0.406
  TNBCa Mann-Whitney U test T = -0.399 P = 0.699 T = -0.310 P = 0.765 T = -0.365 P = 0.725 T = 0.281 P = 0.785
  P53a Mann-Whitney U test T = 0.256 P = 0.800 T = 1.041 P = 0.304 T = 1.617 P = 0.113 T = -0.953 P = 0.347
RECIST Progressive diseasea Mann-Whitney U test T = -2.404 P = 0.019 T = -0.998 P = 0.322 T = -2.488 P = 0.016 T = -0.399 P = 0.691
Circulating markers Number CTCs Spearman correlation R = 0.056 P = 0.635 R = -0.026 P = 0.826 R = 0.053 P = 0.655 R = -0.094 P = 0.424
  ADNAGena Mann-Whitney U test T = -0.534 P = 0.596 T = 1.789 P = 0.078 T = 0.782 P = 0.437 T = -2.144 P = 0.041
  Mammaglobin expression Spearman correlation R = 0.047 P = 0.697 R = 0.005 P = 0.969 R = 0.086 P = 0.474 R = -0.107 P = 0.374
  Cytokeratin 19 expression Spearman correlation R = 0.191 P = 0.110 R = -0.099 P = 0.409 R = -0.010 P = 0.933 R = 0.004 P = 0.968
  Plasma DNA concentration Spearman correlation R = 0.200 P = 0.085 R = -0.100 P = 0.392 R = -0.043 P = 0.712 R = 0.085 P = 0.467
Methylated markers RASSF1A Spearman correlation R = -0.129 P = 0.271 R = -0.198 P = 0.089 R = -0.189 P = 0.104 R = 0.025 P = 0.829
  APC Spearman correlation R = -0.144 P = 0.217 R = -0.134 P = 0.253 R = -0.114 P = 0.332 R = -0.010 P = 0.930
  ESR1 Spearman correlation R = 0.148 P = 0.205 R = 0.001 P = 0.997 R = 0.086 P = 0.461 R = 0.252 P = 0.029
  Number methylated genes Spearman correlation R = 0.250 P = 0.031 R = -0.159 P = 0.172 R = -0.039 P = 0.740 R = 0.262 P = 0.023
  Methylation statusa Mann-Whitney U test T = -1.583 P = 0.118 T = 1.456 P = 0.152 T = 0.538 P = 0.593 T = -1.270 P = 0.208
  1. aA negative T-value indicates a higher expression in the "positive" group.