Group

Variable

Test

MIR215

MIR2995p

MIR411

MIR452


  
Result

Pvalue

Result

Pvalue

Result

Pvalue

Result

Pvalue


Clinicopathologic

Age

Spearman correlation

R = 0.184

P
= 0.113

R = 0.455

P
< 0.001

R = 0.362

P
= 0.001

R = 0.052

P = 0.657


ER^{a}

MannWhitney U test

T = 1.059

P = 0.295

T = 0.658

P = 0.516

T = 0.305

P = 0.763

T = 1.194

P = 0.244


PR^{a}

MannWhitney U test

T = 0.672

P = 0.504

T = 0.193

P = 0.848

T = 0.645

P = 0.521

T = 1.519

P = 0.136


HR^{a}

MannWhitney U test

T = 1.233

P = 0.225

T = 0.632

P = 0.534

T = 0.299

P = 0.767

T = 1.015

P = 0.321


ERBB2^{a}

MannWhitney U test

T = 0.051

P = 0.960

T = 1.237

P = 0.222

T = 1.594

P = 0.120

T = 0.841

P = 0.406


TNBC^{a}

MannWhitney U test

T = 0.399

P = 0.699

T = 0.310

P = 0.765

T = 0.365

P = 0.725

T = 0.281

P = 0.785


P53^{a}

MannWhitney U test

T = 0.256

P = 0.800

T = 1.041

P = 0.304

T = 1.617

P
= 0.113

T = 0.953

P = 0.347

RECIST

Progressive disease^{a}

MannWhitney U test

T = 2.404

P
= 0.019

T = 0.998

P = 0.322

T = 2.488

P
= 0.016

T = 0.399

P = 0.691

Circulating markers

Number CTCs

Spearman correlation

R = 0.056

P = 0.635

R = 0.026

P = 0.826

R = 0.053

P = 0.655

R = 0.094

P = 0.424


ADNAGen^{a}

MannWhitney U test

T = 0.534

P = 0.596

T = 1.789

P
= 0.078

T = 0.782

P = 0.437

T = 2.144

P
= 0.041


Mammaglobin expression

Spearman correlation

R = 0.047

P = 0.697

R = 0.005

P = 0.969

R = 0.086

P = 0.474

R = 0.107

P = 0.374


Cytokeratin 19 expression

Spearman correlation

R = 0.191

P
= 0.110

R = 0.099

P = 0.409

R = 0.010

P = 0.933

R = 0.004

P = 0.968


Plasma DNA concentration

Spearman correlation

R = 0.200

P
= 0.085

R = 0.100

P = 0.392

R = 0.043

P = 0.712

R = 0.085

P = 0.467

Methylated markers

RASSF1A

Spearman correlation

R = 0.129

P = 0.271

R = 0.198

P = 0.089

R = 0.189

P
= 0.104

R = 0.025

P = 0.829


APC

Spearman correlation

R = 0.144

P = 0.217

R = 0.134

P = 0.253

R = 0.114

P = 0.332

R = 0.010

P = 0.930


ESR1

Spearman correlation

R = 0.148

P = 0.205

R = 0.001

P = 0.997

R = 0.086

P = 0.461

R = 0.252

P
= 0.029


Number methylated genes

Spearman correlation

R = 0.250

P
= 0.031

R = 0.159

P = 0.172

R = 0.039

P = 0.740

R = 0.262

P
= 0.023


Methylation status^{a}

MannWhitney U test

T = 1.583

P
= 0.118

T = 1.456

P = 0.152

T = 0.538

P = 0.593

T = 1.270

P = 0.208

 ^{a}A negative Tvalue indicates a higher expression in the "positive" group.