Comparison of normal breast samples with tumor samples. We identified 59 differentially expressed miRNAs between tumor samples and normal breast samples. The median expression of these miRNAs is significantly elevated in normal breast samples, as illustrated by the boxplot (A). The top four miRNAs (miR-215, miR-299-5p, miR-411, and miR-452) with the greatest difference between normal breast samples and breast tumor samples by fold change are depicted in panels B through E. The corresponding false discovery rate is provided in top of each boxplot. All miRNAs are significantly overexpressed in normal breast samples.