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Figure 3 | Breast Cancer Research

Figure 3

From: Expression profiling of cancerous and normal breast tissues identifies microRNAs that are differentially expressed in serum from patients with (metastatic) breast cancer and healthy volunteers

Figure 3

Comparison of the mRNA-based molecular subtype classification by using the SSP method with the miRNA-based classification by using the expression centroids reported by Blenkiron and colleagues. This analysis was performed only for those samples for which Affymetrix mRNA-expression profiles are available (N = 66). The SSP-classification is provided in the X-axis (B, Basal; E, ErbB2+; LA, Luminal A; LB, Luminal B; N, Normal-like; and R, Rest). The Spearman correlation coefficients resulting from the miRNA-based molecular subtype classification are indicated in the Y-axis. For each miRNA-based molecular subtype-specific centroid and each sample in our data set, the Spearman correlation coefficients were determined. The molecular subtype-specific correlation coefficients were statistically compared between samples belonging to and not belonging to the SSP-defined molecular subtype of interest. P values are indicated under the corresponding boxplots.

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Breast Cancer Research

ISSN: 1465-542X

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