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Table 4 Competing risk analysis*.

From: Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2mutation carriers

     

Breast cancer

Ovarian cancer

  

Unaffected

N (%)

Breast

cancer

N (%)

Ovarian

cancer

N (%)

HR

95% CI

P-value

HR

95% CI

P-value

CDK2NA/B - rs1011970

         

BRCA1

GG

3,328 (69.6)

4,424 (69.9)

1,026 (70.1)

1

  

1

  
 

GT

1,309 (27.4)

1,710 (27.0)

398 (27.2)

1.03

0.95 to 1.11

 

1.10

0.95 to 1.26

 
 

TT

142 (3.0)

194 (3.1)

39 (2.7)

1.09

0.88 to 1.35

 

0.90

0.61 to 1.32

 
 

2-df test

     

0.57

  

0.35

 

per allele

   

1.04

0.91 to 1.11

0.30

1.04

0.93 to 1.17

0.48

BRCA2

GG

1,972 (68.6)

2578 (67.9)

315 (69.5)

1

  

1

  
 

GT

815 (28.4)

1097 (28.9)

129 (28.5)

1.09

0.98 to 1.21

 

1.07

0.85 to 1.35

 
 

TT

86 (3.0)

122 (3.2)

9 (2.0)

1.19

0.91 to 1.57

 

0.84

0.40 to 1.77

 
 

2-df test

     

0.15

  

0.74

 

per allele

   

1.09

1.00 to 1.19

0.05

1.03

0.84 to 1.25

0.81

ZNF365 - rs10995190

          

BRCA1

GG

3,408 (71.3)

4,523 (71.5)

1,019 (69.6)

1

  

1

  
 

GA

1,258 (26.3)

1,650 (26.1)

410 (28.0)

1.00

0.93 to 1.08

 

1.12

0.98 to 1.28

 
 

AA

113 (2.4)

155 (2.5)

35 (2.4)

0.96

0.78 to 1.20

 

0.90

0.61 to 1.33

 
 

2-df test

     

0.94

  

0.23

 

per allele

   

0.99

0.93 to 1.06

0.88

1.06

0.95 to 1.19

0.32

BRCA2

GG

2,033 (70.4)

2,795 (73.7)

318 (70.2)

1

  

1

  
 

GA

794 (27.7)

920 (24.3)

122 (26.9)

0.86

0.78 to 0.96

 

0.99

0.78 to 1.25

 
 

AA

55 (1.9)

79 (2.1)

13 (2.9)

1.03

0.74 to 1.43

 

1.58

0.83 to 3.03

 
 

2-df test

     

0.02

  

0.37

 

per allele

   

0.90

0.82 to 0.99

0.03

1.06

0.87 to 1.31

0.55

ZMIZ1 - rs704010

          

BRCA1

CC

1,904 (40.2)

2,493 (40.0)

583 (40.1)

1

  

1

  
 

CT

2,172 (45.9)

2,871 (46.0)

665 (45.7)

1.02

0.95 to 1.10

 

1.01

0.89 to 1.15

 
 

TT

660 (13.9)

877 (14.1)

206 (14.2)

1.02

0.92 to 1.14

 

1.01

0.84 to 1.22

 
 

2-df test

     

0.67

  

0.99

 

per allele

   

1.01

0.97 to 1.07

0.58

1.01

0.92 to 1.10

0.90

BRCA2

CC

1,109 (39.0)

1,439 (38.4)

181 (40.1)

1

  

1

  
 

CT

1,306 (46.0)

1,774 (47.3)

192 (43.4)

1.06

0.96 to 1.17

 

0.96

0.76 to 1.20

 
 

TT

426 (15.0)

538 (14.3)

69 (15.6)

1.00

0.86 to 1.15

 

1.05

0.77 to 1.43

 
 

2-df test

     

0.46

  

0.81

 

per allele

   

1.01

0.95 to 1.08

0.72

1.01

0.87 to 1.18

0.90

10p15 - rs2380205

        

BRCA1

CC

1,183 (32.2)

1,698 (32.1)

438 (33.2)

1

  

1

  
 

CT

1,796 (48.9)

2,605 (49.3)

634 (48.1)

0.99

0.91 to 1.08

 

0.91

0.79 to 1.05

 
 

TT

696 (18.9)

981 (18.6)

246 (18.7)

1.00

0.90 to 1.12

 

0.94

0.78 to 1.14

 
 

2-df test

     

0.96

  

0.45

 

per allele

   

1.00

0.95 to 1.06

0.98

0.96

0.87 to 1.06

0.40

BRCA2

CC

872 (32.6)

1,161 (31.8)

143 (33.7)

1

  

1

  
 

CT

1,321 (49.4)

1,812 (49.6)

199 (46.9)

1.04

0.94 to 1.16

 

0.94

0.74 to 1.19

 
 

TT

481 (18.0)

678 (18.6)

82 (19.3)

1.03

0.90 to 1.18

 

1.01

0.75 to 1.38

 
 

2-df test

     

0.74

  

0.82

 

per allele

   

1.02

0.95 to 1.09

0.61

1.00

0.85 to 1.16

0.98

11q13 - rs614367

        

BRCA1

CC

3,439 (72.3)

4,547 (72.1)

1,111 (76.2)

1

  

1

  
 

CT

1,212 (25.5)

1,606 (25.5)

311 (21.3)

1.02

0.94 to 1.11

 

0.83

0.72 to 0.96

 
 

TT

109 (2.3)

154 (2.4)

37 (2.5)

1.12

0.91 to 1.39

 

1.20

0.81 to 1.76

 
 

2-df test

     

0.52

  

0.03

 

per allele

   

1.03

0.91 to 1.10

0.35

0.91

0.80 to 1.03

0.13

BRCA2

CC

2,106 (73.5)

2,716 (71.9)

333 (73.8)

1

  

1

  
 

CT

693 (24.2)

981 (26.0)

108 (24.0)

1.05

0.95 to 1.16

 

0.95

0.74 to 1.21

 
 

TT

66 (2.3)

83 (2.2)

10 (2.2)

0.96

0.71 to 1.28

 

0.87

0.46 to 1.63

 
 

2-df test

     

0.62

  

0.84

 

per allele

   

1.03

0.94 to 1.12

0.56

0.94

0.77 to 1.15

0.56

12q24 - rs1292011

        

BRCA1

AA

997 (34.1)

1,321 (35.4)

305 (34.9)

1

  

1

  
 

AG

1,406 (48.2)

1,765 (47.3)

429 (49.1)

1.00

0.90 to 1.10

 

1.11

0.93 to 1.31

 
 

GG

517 (17.7)

645 (17.3)

140 (16.0)

1.01

0.89 to 1.15

 

0.98

0.78 to 1.24

 
 

2-df test

     

0.97

  

0.39

 

per allele

   

1.00

0.94 to 1.07

0.91

1.01

0.91 to 1.13

0.82

BRCA2

AA

715 (35.0)

907 (35.9)

110 (36.5)

1

  

1

  
 

AG

961 (47.0)

1222 (48.4)

137 (45.5)

1.02

0.90 to 1.15

 

0.94

0.71 to 1.25

 
 

GG

370 (18.1)

396 (15.7)

54 (17.9)

0.83

0.70 to 0.97

 

0.89

0.61 to 1.28

 
 

2-df test

     

0.03

  

0.80

 

per allele

   

0.93

0.86 to 1.00

0.07

0.94

0.78 to 1.13

0.51

PTHLH - rs10771399

        

BRCA1

AA

3,810 (79.8)

5,179 (81.9)

1,145 (78.4)

1

  

1

  
 

AG

909 (19.0)

1078 (17.1)

289 (19.8)

0.89

0.81 to 0.97

 

1.09

0.93 to 1.26

 
 

GG

56 (1.2)

65 (1.0)

27 (1.9)

0.86

0.63 to 1.16

 

1.67

1.05 to 2.64

 
 

2-df test

     

0.02

  

0.06

 

per allele

   

0.90

0.83 to 0.97

6.4 × 10 -3

1.14

1.00 to 1.30

0.06

BRCA2

AA

2,289 (79.7)

3,076 (81.2)

369 (81.5)

1

  

1

  
 

AG

545 (19.0)

678 (17.9)

76 (16.8)

0.94

0.84 to 1.06

 

0.88

0.67 to 1.16

 
 

GG

37 (1.3)

34 (0.9)

8 (1.8)

0.79

0.49 to 1.26

 

1.48

0.63 to 3.46

 
 

2-df test

     

0.38

  

0.43

 

per allele

   

0.93

0.84 to 1.04

0.19

0.96

0.75 to 1.23

0.75

9q31.2 - rs865686

        

BRCA1

TT

1,935 (40.5)

2,621 (41.5)

605 (41.3)

1

  

1

  
 

TG

2,206 (46.2)

2,825 (44.7)

690 (47.1)

0.94

0.88 to 1.01

 

0.99

0.87 to 1.12

 
 

GG

633 (13.3)

877 (13.9)

169 (11.5)

1.03

0.93 to 1.15

 

0.85

0.70 to 1.03

 
 

2-df test

     

0.12

  

0.23

 

per allele

   

1.00

0.95 to 1.05

0.88

0.94

0.86 to 1.03

0.17

BRCA2

TT

1,103 (38.4)

1,576 (41.6)

179 (39.6)

1

  

1

  
 

TG

1400 (48.8)

1712 (45.2)

215 (47.6)

0.85

0.77 to 0.94

 

0.91

0.73 to 1.14

 
 

GG

367 (12.8)

501 (13.2)

58 (12.8)

0.97

0.84 to 1.12

 

0.98

0.71 to 1.35

 
 

2-df test

     

4.6 × 10 -3

  

0.70

 

per allele

   

0.94

0.88 to 1.01

0.10

0.97

0.83 to 1.13

0.67

  1. Associations with breast and ovarian cancer risk for BRCA1 and BRCA2 carriers.
  2. *Censoring process described in the methods
  3. HR, hazard ratio
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Breast Cancer Research

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