| Unaffected, N | Affected, N | HR | 95% CI | P-value |
---|---|---|---|---|---|
Excluding prevalent breast cancer cases | |||||
CDK2NA/B -rs1011970 | Â | Â | Â | Â | Â |
BRCA1 | 6,200 | 3,152 | 1.05 | 0.98 to 1.14 | 0.18 |
BRCA2 | 3,319 | 1,950 | 1.10 | 1.00 to 1.22 | 0.05 |
ZNF365 - rs10995190 | Â | Â | Â | Â | Â |
BRCA1 | 6,201 | 3,151 | 0.96 | 0.89 to 1.04 | 0.34 |
BRCA2 | 3,318 | 1,949 | 0.90 | 0.81 to 1.00 | 0.05 |
ZMIZ1 - rs704010 | Â | Â | Â | Â | Â |
BRCA1 | 6,149 | 3,094 | 1.02 | 0.96 to 1.08 | 0.53 |
BRCA2 | 3,276 | 1,919 | 0.98 | 0.91 to 1.06 | 0.64 |
10p15 - rs2380205 | Â | ||||
BRCA1 | 4,955 | 2,764 | 1.02 | 0.95 to 1.08 | 0.64 |
BRCA2 | 3,092 | 1,884 | 1.00 | 0.93 to 1.08 | 0.92 |
11q13 - rs614367 | Â | Â | Â | Â | Â |
BRCA1 | 6,177 | 3,144 | 1.01 | 0.94 to 1.10 | 0.73 |
BRCA2 | 3,310 | 1,944 | 0.99 | 0.89 to 1.10 | 0.88 |
12q24 - rs1292011 | Â | Â | Â | Â | Â |
BRCA1 | 3,773 | 1,798 | 1.04 | 0.97 to 1.12 | 0.29 |
BRCA2 | 2,345 | 1,220 | 0.96 | 0.88 to 1.06 | 0.41 |
PTHLH - rs10771399 | Â | Â | Â | Â | Â |
BRCA1 | 6,194 | 3,152 | 0.85 | 0.77 to 0.93 | 5.8 × 10-4 |
BRCA2 | 3,317 | 1,944 | 0.89 | 0.78 to 1.00 | 0.06 |
9q31.2 - rs865686 | Â | Â | Â | Â | Â |
BRCA1 | 6,196 | 3,149 | 1.01 | 0.95 to 1.07 | 0.72 |
BRCA2 | 3,315 | 1,946 | 0.94 | 0.87 to 1.02 | 0.15 |
BRCA1 analysis by mutation class | Â | Â | Â | Â | Â |
CDK2NA/B -rs1011970 | Â | Â | Â | Â | Â |
Class1 | 4,040 | 3,843 | 1.01 | 0.94 to 1.10 | 0.72 |
Class2 | 1,771 | 1,958 | 1.03 | 0.91 to 1.16 | 0.66 |
ZNF365 - rs10995190 | Â | Â | Â | Â | Â |
Class1 | 4,058 | 3,844 | .99 | 0.92 to 1.07 | 0.80 |
Class2 | 1,774 | 1,957 | 0.97 | 0.86 to 1.09 | 0.59 |
ZMIZ1 - rs704010 | Â | Â | Â | Â | Â |
Class1 | 3,998 | 3,787 | 1.04 | 0.98 to 1.10 | 0.22 |
Class2 | 1,767 | 1,936 | 1.01 | 0.92 to 1.11 | 0.85 |
10p15 - rs2380205 | |||||
Class1 | 3,664 | 3,538 | 1.01 | 0.95 to 1.07 | 0.82 |
Class2 | 931 | 1,263 | 1.03 | 0.91 to 1.15 | 0.67 |
11q13 - rs614367 | Â | Â | Â | Â | Â |
Class1 | 4,024 | 3,833 | 1.10 | 1.02 to 1.19 | 0.02 |
Class2 | 1,764 | 1,948 | 0.94 | 0.84 to 1.06 | 0.32 |
12q24 - rs1292011 | Â | Â | Â | Â | Â |
Class1 | 2,812 | 2,521 | 0.99 | 0.92 to 1.06 | 0.71 |
Class2 | 642 | 797 | 0.97 | 0.84 to 1.12 | 0.68 |
PTHLH - rs10771399 | Â | Â | Â | Â | Â |
Class1 | 4,035 | 3,841 | 0.82 | 0.74 to 0.90 | 3.1 × 10-5 |
Class2 | 1,770 | 1,953 | 1.00 | 0.87 to 1.15 | 0.99 |
9q31.2 - rs865686 | Â | Â | Â | Â | Â |
Class1 | 4,038 | 3,840 | 0.98 | 0.92 to 1.04 | 0.48 |
Class2 | 1,769 | 1,957 | 1.03 | 0.94 to 1.14 | 0.49 |