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Table 3 Associations with breast cancer risk, after excluding prevalent breast cancer cases, and BRCA1 mutation class.

From: Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2mutation carriers

  Unaffected, N Affected, N HR 95% CI P-value
Excluding prevalent breast cancer cases
CDK2NA/B -rs1011970      
BRCA1 6,200 3,152 1.05 0.98 to 1.14 0.18
BRCA2 3,319 1,950 1.10 1.00 to 1.22 0.05
ZNF365 - rs10995190      
BRCA1 6,201 3,151 0.96 0.89 to 1.04 0.34
BRCA2 3,318 1,949 0.90 0.81 to 1.00 0.05
ZMIZ1 - rs704010      
BRCA1 6,149 3,094 1.02 0.96 to 1.08 0.53
BRCA2 3,276 1,919 0.98 0.91 to 1.06 0.64
10p15 - rs2380205  
BRCA1 4,955 2,764 1.02 0.95 to 1.08 0.64
BRCA2 3,092 1,884 1.00 0.93 to 1.08 0.92
11q13 - rs614367      
BRCA1 6,177 3,144 1.01 0.94 to 1.10 0.73
BRCA2 3,310 1,944 0.99 0.89 to 1.10 0.88
12q24 - rs1292011      
BRCA1 3,773 1,798 1.04 0.97 to 1.12 0.29
BRCA2 2,345 1,220 0.96 0.88 to 1.06 0.41
PTHLH - rs10771399      
BRCA1 6,194 3,152 0.85 0.77 to 0.93 5.8 × 10-4
BRCA2 3,317 1,944 0.89 0.78 to 1.00 0.06
9q31.2 - rs865686      
BRCA1 6,196 3,149 1.01 0.95 to 1.07 0.72
BRCA2 3,315 1,946 0.94 0.87 to 1.02 0.15
BRCA1 analysis by mutation class      
CDK2NA/B -rs1011970      
Class1 4,040 3,843 1.01 0.94 to 1.10 0.72
Class2 1,771 1,958 1.03 0.91 to 1.16 0.66
ZNF365 - rs10995190      
Class1 4,058 3,844 .99 0.92 to 1.07 0.80
Class2 1,774 1,957 0.97 0.86 to 1.09 0.59
ZMIZ1 - rs704010      
Class1 3,998 3,787 1.04 0.98 to 1.10 0.22
Class2 1,767 1,936 1.01 0.92 to 1.11 0.85
10p15 - rs2380205
Class1 3,664 3,538 1.01 0.95 to 1.07 0.82
Class2 931 1,263 1.03 0.91 to 1.15 0.67
11q13 - rs614367      
Class1 4,024 3,833 1.10 1.02 to 1.19 0.02
Class2 1,764 1,948 0.94 0.84 to 1.06 0.32
12q24 - rs1292011      
Class1 2,812 2,521 0.99 0.92 to 1.06 0.71
Class2 642 797 0.97 0.84 to 1.12 0.68
PTHLH - rs10771399      
Class1 4,035 3,841 0.82 0.74 to 0.90 3.1 × 10-5
Class2 1,770 1,953 1.00 0.87 to 1.15 0.99
9q31.2 - rs865686      
Class1 4,038 3,840 0.98 0.92 to 1.04 0.48
Class2 1,769 1,957 1.03 0.94 to 1.14 0.49
  1. HR, hazard ratio