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Table 3 Associations with breast cancer risk, after excluding prevalent breast cancer cases, and BRCA1 mutation class.

From: Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2mutation carriers

 

Unaffected, N

Affected, N

HR

95% CI

P-value

Excluding prevalent breast cancer cases

CDK2NA/B -rs1011970

     

BRCA1

6,200

3,152

1.05

0.98 to 1.14

0.18

BRCA2

3,319

1,950

1.10

1.00 to 1.22

0.05

ZNF365 - rs10995190

     

BRCA1

6,201

3,151

0.96

0.89 to 1.04

0.34

BRCA2

3,318

1,949

0.90

0.81 to 1.00

0.05

ZMIZ1 - rs704010

     

BRCA1

6,149

3,094

1.02

0.96 to 1.08

0.53

BRCA2

3,276

1,919

0.98

0.91 to 1.06

0.64

10p15 - rs2380205

 

BRCA1

4,955

2,764

1.02

0.95 to 1.08

0.64

BRCA2

3,092

1,884

1.00

0.93 to 1.08

0.92

11q13 - rs614367

     

BRCA1

6,177

3,144

1.01

0.94 to 1.10

0.73

BRCA2

3,310

1,944

0.99

0.89 to 1.10

0.88

12q24 - rs1292011

     

BRCA1

3,773

1,798

1.04

0.97 to 1.12

0.29

BRCA2

2,345

1,220

0.96

0.88 to 1.06

0.41

PTHLH - rs10771399

     

BRCA1

6,194

3,152

0.85

0.77 to 0.93

5.8 × 10-4

BRCA2

3,317

1,944

0.89

0.78 to 1.00

0.06

9q31.2 - rs865686

     

BRCA1

6,196

3,149

1.01

0.95 to 1.07

0.72

BRCA2

3,315

1,946

0.94

0.87 to 1.02

0.15

BRCA1 analysis by mutation class

     

CDK2NA/B -rs1011970

     

Class1

4,040

3,843

1.01

0.94 to 1.10

0.72

Class2

1,771

1,958

1.03

0.91 to 1.16

0.66

ZNF365 - rs10995190

     

Class1

4,058

3,844

.99

0.92 to 1.07

0.80

Class2

1,774

1,957

0.97

0.86 to 1.09

0.59

ZMIZ1 - rs704010

     

Class1

3,998

3,787

1.04

0.98 to 1.10

0.22

Class2

1,767

1,936

1.01

0.92 to 1.11

0.85

10p15 - rs2380205

Class1

3,664

3,538

1.01

0.95 to 1.07

0.82

Class2

931

1,263

1.03

0.91 to 1.15

0.67

11q13 - rs614367

     

Class1

4,024

3,833

1.10

1.02 to 1.19

0.02

Class2

1,764

1,948

0.94

0.84 to 1.06

0.32

12q24 - rs1292011

     

Class1

2,812

2,521

0.99

0.92 to 1.06

0.71

Class2

642

797

0.97

0.84 to 1.12

0.68

PTHLH - rs10771399

     

Class1

4,035

3,841

0.82

0.74 to 0.90

3.1 × 10-5

Class2

1,770

1,953

1.00

0.87 to 1.15

0.99

9q31.2 - rs865686

     

Class1

4,038

3,840

0.98

0.92 to 1.04

0.48

Class2

1,769

1,957

1.03

0.94 to 1.14

0.49

  1. HR, hazard ratio