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Table 1 Summary characteristics for the 19731 eligible BRCA1 and BRCA2 carriers* used in the analysis

From: Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2mutation carriers

Characteristic BRCA1 BRCA2
  Unaffected Breast cancer Unaffected Breast cancer
Number 6,209 6,390 3,322 3,810
Person-years follow-up 264,903 263,068 147,053 168,201
Median age at censure (IQR1) 42 (34 to 50) 40 (34 to 47) 43 (34 to 53) 43 (37 to 50)
Age at censure, N (%)     
< 30 1,189 (19.2) 691 (10.8) 611 (18.4) 306 (8.0)
30 to 39 1,161 (26.8) 2,445 (38.3) 834 (25.1) 1,141 (30.0)
40 to 49 1,765 (28.4) 2,191 (34.3) 865 (26.0) 1,394 (36.6)
50 to 59 1,058 (17.0) 812 (12.7) 566 (17.0) 687 (18.0)
60 to 69 380 (6.1) 198 (3.1) 302 (9.1) 226 (5.9)
70+ 156 (2.5) 53 (0.8) 144 (4.3) 56 (1.5)
Year of birth, N (%)     
< 1920 28 (0.5) 30 (0.5) 23 (0.7) 44 (1.2)
1920 to 1929 131 (2.1) 196 (3.1) 99 (3.0) 167 (4.4)
1930 to 1939 369 (5.9) 516 (8.1) 232 (7.0) 430 (11.3)
1940 to 1949 832 (13.4) 1,341 (21.0) 458 (13.8) 896 (23.5)
1950 to 1959 1,409 (22.7) 1,989 (31.1) 691 (20.8) 1,160 (30.5)
1960 to 1969 1,703 (27.4) 1,666 (26.1) 902 (27.2) 868 (22.8)
1970+ 1,737 (28.0) 652 (10.2) 917 (27.6) 245 (6.4)
Mutation Class, N (%)     
Class 12 4,063 (65.4) 3,878 (60.7) 3,114 (93.7) 3,520 (92.4)
Class 22 1,780 (28.7) 1,973 (30.9) 72 (2.2) 100 (2.6)
Other 366 (5.9) 539 (8.4) 136 (4.1) 190 (5.0)
  1. 1 IQR: Interquartile Range
  2. 2 See methods for definitions
  3. * Carriers of self-reported white European ancestry only.