Table 1 Summary characteristics for the 19731 eligible BRCA1 and BRCA2 carriers* used in the analysis
Characteristic | BRCA1 | BRCA2 | ||
|---|---|---|---|---|
| Â | Unaffected | Breast cancer | Unaffected | Breast cancer |
Number | 6,209 | 6,390 | 3,322 | 3,810 |
Person-years follow-up | 264,903 | 263,068 | 147,053 | 168,201 |
Median age at censure (IQR1) | 42 (34 to 50) | 40 (34 to 47) | 43 (34 to 53) | 43 (37 to 50) |
Age at censure, N (%) | Â | Â | Â | Â |
< 30 | 1,189 (19.2) | 691 (10.8) | 611 (18.4) | 306 (8.0) |
30 to 39 | 1,161 (26.8) | 2,445 (38.3) | 834 (25.1) | 1,141 (30.0) |
40 to 49 | 1,765 (28.4) | 2,191 (34.3) | 865 (26.0) | 1,394 (36.6) |
50 to 59 | 1,058 (17.0) | 812 (12.7) | 566 (17.0) | 687 (18.0) |
60 to 69 | 380 (6.1) | 198 (3.1) | 302 (9.1) | 226 (5.9) |
70+ | 156 (2.5) | 53 (0.8) | 144 (4.3) | 56 (1.5) |
Year of birth, N (%) | Â | Â | Â | Â |
< 1920 | 28 (0.5) | 30 (0.5) | 23 (0.7) | 44 (1.2) |
1920 to 1929 | 131 (2.1) | 196 (3.1) | 99 (3.0) | 167 (4.4) |
1930 to 1939 | 369 (5.9) | 516 (8.1) | 232 (7.0) | 430 (11.3) |
1940 to 1949 | 832 (13.4) | 1,341 (21.0) | 458 (13.8) | 896 (23.5) |
1950 to 1959 | 1,409 (22.7) | 1,989 (31.1) | 691 (20.8) | 1,160 (30.5) |
1960 to 1969 | 1,703 (27.4) | 1,666 (26.1) | 902 (27.2) | 868 (22.8) |
1970+ | 1,737 (28.0) | 652 (10.2) | 917 (27.6) | 245 (6.4) |
Mutation Class, N (%) | Â | Â | Â | Â |
Class 12 | 4,063 (65.4) | 3,878 (60.7) | 3,114 (93.7) | 3,520 (92.4) |
Class 22 | 1,780 (28.7) | 1,973 (30.9) | 72 (2.2) | 100 (2.6) |
Other | 366 (5.9) | 539 (8.4) | 136 (4.1) | 190 (5.0) |