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Table 6 Prospective studies of testosterone and breast cancer risk in premenopausal womena

From: Premenopausal serum androgens and breast cancer risk: a nested case-control study

Study

Number of

Cases/Controls

Mean (SD)

age at baseline for cases, yrs

Phase of cycle when

blood was drawn

Mean follow-up

duration, yrs

Menopausal status

at diagnosis

Assay method

Testosterone Odds Ratiob

(95% CI)

P trend

Free Testosteronec Odds Ratiob

(95% CI)

P trend

Guernsey

(Thomas et al. 1997)

62/182

40.9 (0.6)

Any

8.0

(range: < 1-16)

Not given

Direct radioimmunoassay

1.2 (0.6 to 2.4)

0.57

Not done

N/A

ORDET

(Micheli et al. 2004)

65/243

44.3 (4.9)

Luteal

5.2

(range: 3 to 8)

Not given

Direct

radioimmunoassay

1.0 (ref)

1.1 (0.4 to3.0)

2.2 (0.6 to7.6)

0.28

1.0 (ref)

1.9 (0.6 to 5.8)

3.1 (0.9 to10.9)

0.08

EPIC

(Kaaks et al. 2005)

370/726

45.6 (7.6)

Any

2.8

(range: 0.2 to 5.8)

Not given

Age < 49: 47%

Direct

radioimmunoassay

1.0 (ref)

1.4 (1.0 tp 2.1)

1.4 (0.9 to 2.0)

1.7 (1.2 to 2.6)

0.01

Not done

N/A

NHS II

(Eliassen et al. 2006)

197/394

43.4 (3.8)

Follicular

2.9

(range: 0.1 to 7.3)

Pred

Extraction, chromatography, radioimmunoassay

1.0 (ref)

1.3 (0.8 to 2.2)

1.4 (0.8 to 2.3)

1.3 (0.8 to 2.4)

0.35

1.0 (ref)

1.5 (0.8 to 2.6)

1.5 (0.9 to 2.6)

1.6 (0.9 to 2.8)

0.17

   

Luteal

   

1.0 (ref)

1.3 (0.8 to 2.3)

1.4 (0.8 to 2.3)

1.6 (0.9 to 2.8)

0.10

1.0 (ref)

0.9 (0.5 to 1.5)

1.3 (0.7 to 2.2)

1.4 (0.8 to 2.5)

0.14

Columbia Serum Bank

(Dorgan et al. 2010)

98/168

44.7 (4.8)

Any

14.0

(SD: 6.6)

Not given

Age ≥65: 68%

Extraction, chromatography, radioimmunoassay

1.0 (ref)

2.1 (0.9 to 4.8)

1.5 (0.6 to 3.4)

3.3 (1.5 to 7.5)

< 0.01

1.0 (ref)

1.7 (0.7 to 4.2)

1.7 (0.7 to 4.0)

4.2 (1.6 to 10.9)

< 0.01

NYUWHS

356/683

44.3 (4.9)

Any

13.1

(SD: 1.9)

Pre: 49%

Post: 51%

Direct

radioimmunoassay

1.0 (ref)

1.5 (0.9 to 2.3)

1.2 (0.7 to 1.9)

1.4 (0.9 to 2.3)

1.8 (1.1 to 2.9)

0.04

1.0 (ref)

1.2 (0.7 to 1.8)

1.5 (0.9 to 2.3)

1.5 (0.9 to 2.3)

1.8 (1.1 to 2.8)

0.01

  1. aWysowski et al. [9] not included in table because no odds ratio was provided (no statistical difference was observed in testosterone concentrations in 17 women). bOdds Ratios (95% CIs) based on a 1 unit increase in the natural log of hormone concentration, tertiles, quartiles, or quintiles of serum concentration. cBioavailable testosterone (free plus albumin bound) calculated in Dorgan et al. 2010 study. dExcept for five women.
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Breast Cancer Research

ISSN: 1465-542X

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