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Table 6 Prospective studies of testosterone and breast cancer risk in premenopausal womena

From: Premenopausal serum androgens and breast cancer risk: a nested case-control study

Study Number of
Cases/Controls
Mean (SD)
age at baseline for cases, yrs
Phase of cycle when
blood was drawn
Mean follow-up
duration, yrs
Menopausal status
at diagnosis
Assay method Testosterone Odds Ratiob
(95% CI)
P trend Free Testosteronec Odds Ratiob
(95% CI)
P trend
Guernsey
(Thomas et al. 1997)
62/182 40.9 (0.6) Any 8.0
(range: < 1-16)
Not given Direct radioimmunoassay 1.2 (0.6 to 2.4) 0.57 Not done N/A
ORDET
(Micheli et al. 2004)
65/243 44.3 (4.9) Luteal 5.2
(range: 3 to 8)
Not given Direct
radioimmunoassay
1.0 (ref)
1.1 (0.4 to3.0)
2.2 (0.6 to7.6)
0.28 1.0 (ref)
1.9 (0.6 to 5.8)
3.1 (0.9 to10.9)
0.08
EPIC
(Kaaks et al. 2005)
370/726 45.6 (7.6) Any 2.8
(range: 0.2 to 5.8)
Not given
Age < 49: 47%
Direct
radioimmunoassay
1.0 (ref)
1.4 (1.0 tp 2.1)
1.4 (0.9 to 2.0)
1.7 (1.2 to 2.6)
0.01 Not done N/A
NHS II
(Eliassen et al. 2006)
197/394 43.4 (3.8) Follicular 2.9
(range: 0.1 to 7.3)
Pred Extraction, chromatography, radioimmunoassay 1.0 (ref)
1.3 (0.8 to 2.2)
1.4 (0.8 to 2.3)
1.3 (0.8 to 2.4)
0.35 1.0 (ref)
1.5 (0.8 to 2.6)
1.5 (0.9 to 2.6)
1.6 (0.9 to 2.8)
0.17
    Luteal     1.0 (ref)
1.3 (0.8 to 2.3)
1.4 (0.8 to 2.3)
1.6 (0.9 to 2.8)
0.10 1.0 (ref)
0.9 (0.5 to 1.5)
1.3 (0.7 to 2.2)
1.4 (0.8 to 2.5)
0.14
Columbia Serum Bank
(Dorgan et al. 2010)
98/168 44.7 (4.8) Any 14.0
(SD: 6.6)
Not given
Age ≥65: 68%
Extraction, chromatography, radioimmunoassay 1.0 (ref)
2.1 (0.9 to 4.8)
1.5 (0.6 to 3.4)
3.3 (1.5 to 7.5)
< 0.01 1.0 (ref)
1.7 (0.7 to 4.2)
1.7 (0.7 to 4.0)
4.2 (1.6 to 10.9)
< 0.01
NYUWHS 356/683 44.3 (4.9) Any 13.1
(SD: 1.9)
Pre: 49%
Post: 51%
Direct
radioimmunoassay
1.0 (ref)
1.5 (0.9 to 2.3)
1.2 (0.7 to 1.9)
1.4 (0.9 to 2.3)
1.8 (1.1 to 2.9)
0.04 1.0 (ref)
1.2 (0.7 to 1.8)
1.5 (0.9 to 2.3)
1.5 (0.9 to 2.3)
1.8 (1.1 to 2.8)
0.01
  1. aWysowski et al. [9] not included in table because no odds ratio was provided (no statistical difference was observed in testosterone concentrations in 17 women). bOdds Ratios (95% CIs) based on a 1 unit increase in the natural log of hormone concentration, tertiles, quartiles, or quintiles of serum concentration. cBioavailable testosterone (free plus albumin bound) calculated in Dorgan et al. 2010 study. dExcept for five women.