From: Premenopausal serum androgens and breast cancer risk: a nested case-control study

Characteristic | Hormone | ||||
---|---|---|---|---|---|

(number of cases) | Testosterone | Free Testosterone | Androstenedione | DHEAS | SHBG |

All women (n = 354)
| |||||

OR (95% CI) | 1.6 (1.2, 2.3) | 1.3 (1.1, 1.5) | 1.3 (1.0, 1.7) | 1.1 (0.9, 1.4) | 0.9 (0.8, 1.1) |

P-value
| 0.01 | 0.003 | 0.07 | 0.31 | 0.47 |

Tumor type | |||||

Invasive (n = 274)
| |||||

OR (95% CI) | 1.5 (1.1, 2.2) | 1.2 (1.0, 1.4) | 1.3 (0.9, 1.8) | 1.1 (0.8, 1.4) | 1.0 (0.8, 1.2) |

P-value
| 0.03 | 0.02 | 0.11 | 0.60 | 0.84 |

In situ (n = 80)
| |||||

OR (95% CI) | 2.3 (0.9, 5.9) | 1.4 (1.0, 2.1) | 2.0 (0.9, 4.5) | 1.6 (0.9, 2.8) | 0.8 (0.5, 1.3) |

P-value
| 0.09 | 0.07 | 0.10 | 0.14 | 0.37 |

Estrogen receptor status^{b}
| |||||

Positive (n = 104)
| |||||

OR (95% CI) | 2.4 (1.2, 4.6) | 1.6 (1.2, 2.2) | 2.2 (1.3, 3.8) | 1.2 (0.8, 1.8) | 0.9 (0.6, 1.3) |

P-value
| 0.01 | 0.003 | 0.01 | 0.42 | 0.56 |

Negative (n = 60)
| |||||

OR (95% CI) | 1.7 (0.7, 4.3) | 1.2 (0.9, 1.8) | 0.7 (0.3, 1.6) | 1.4 (0.7, 2.6) | 0.8 (0.5, 1.4) |

P-value
| 0.25 | 0.26 | 0.37 | 0.34 | 0.41 |

Age at enrollment^{c}
| |||||

< 40 yrs (n = 77)
| |||||

OR (95% CI) | 1.7 (0.7, 4.2) | 1.3 (0.9, 2.0) | 1.3 (0.6, 2.7) | 0.9 (0.5, 1.5) | 0.7 (0.4, 1.2) |

P-value
| 0.27 | 0.19 | 0.45 | 0.61 | 0.17 |

40- to yrs (n = 117)
| |||||

OR (95% CI) | 1.4 (0.7, 2.6) | 1.1 (0.8, 1.4) | 1.1 (0.7, 1.8) | 1.1 (0.8, 1.6) | 1.2 (0.8, 1.8) |

P-value
| 0.33 | 0.50 | 0.72 | 0.53 | 0.36 |

≥45 yrs (n = 160)
| |||||

OR (95% CI) | 1.9 (1.2, 3.2) | 1.4 (1.1, 1.7) | 1.5 (1.0, 2.3) | 1.2 (0.9, 1.7) | 0.9 (0.7, 1.2) |

P-value
| 0.01 | 0.004 | 0.08 | 0.21 | 0.57 |

Menopausal status at diagnosis^{d, e}
| |||||

Pre (n = 152)
| |||||

OR (95% CI) | 1.4 (0.8, 2.3) | 1.1 (0.9, 1.4) | 1.0 (0.7, 1.5) | 1.1 (0.8, 2.5) | 1.0 (0.8, 1.4) |

P-value
| 0.23 | 0.36 | 0.98 | 0.56 | 0.80 |

Post (n = 161)
| |||||

OR (95% CI) | 1.7 (1.1, 2.6) | 1.3 (1.1, 1.6) | 1.3 (0.9, 1.9) | 1.2 (0.8, 1.6) | 0.9 (0.7, 1.1) |

P-value
| 0.02 | 0.006 | 0.18 | 0.39 | 0.26 |

BMI^{d}
| |||||

< 25 kg/m^{2} (n = 239)
| |||||

OR (95% CI) | 1.8 (1.2, 2.6) | 1.3 (1.1, 1.5) | 1.2 (0.9, 1.6) | 1.3 (1.0, 1.6) | 0.9 (0.7, 1.1) |

P-value
| 0.003 | 0.003 | 0.30 | 0.08 | 0.41 |

25 to 29.9 kg/m^{2} (n = 74)
| |||||

OR (95% CI) | 2.4 (1.1, 5.0) | 1.5 (1.1, 2.1) | 1.9 (1.0, 3.5) | 1.3 (0.8, 2.1) | 1.1 (0.8, 1.7) |

P-value
| 0.02 | 0.01 | 0.05 | 0.29 | 0.58 |

≥30 kg/m^{2} (n = 108)
| |||||

OR (95% CI) | 1.5 (0.8, 2.7) | 1.2 (0.9, 1.6) | 1.6 (1.0, 2.5) | 1.0 (0.7, 1.5) | 1.1 (0.8, 1.5) |

P-value
| 0.20 | 0.11 | 0.08 | 0.95 | 0.64 |

Lag time between blood donation and diagnosis^{f}
| |||||

< 7 yrs (n = 154)
| |||||

OR (95% CI) | 2.0 (1.1, 3.5) | 1.3 (1.0, 1.7) | 1.3 (0.9, 2.1) | 1.4 (1.0, 1.9) | 1.0 (0.8, 1.5) |

P-value
| 0.02 | 0.04 | 0.20 | 0.06 | 0.78 |

≥7 yrs (n = 200)
| |||||

OR (95% CI) | 1.5 (1.0, 2.3) | 1.3 (1.0, 1.5) | 1.3 (0.9, 1.9) | 1.0 (0.7, 1.3) | 0.8 (0.6, 1.1) |

P-value
| 0.07 | 0.02 | 0.17 | 0.80 | 0.22 |

5 to7 cycles in 6 months prior to enrollment and regular cycles^{d} (n = 253)
| |||||

OR (95% CI) | 1.6 (1.1, 2.3) | 1.2 (1.1, 1.5) | 1.3 (1.0, 1.8) | 1.1 (0.9, 1.5) | 0.9 (0.8, 1.2) |

P-value
| 0.02 | 0.01 | 0.07 | 0.29 | 0.59 |