Premenopausal serum androgens and breast cancer risk: a nested case-control study

Zeleniuch-Jacquotte, Anne; Afanasyeva, Yelena; Kaaks, Rudolf; Rinaldi, Sabina; Scarmo, Stephanie; Liu, Mengling; Arslan, Alan A; Toniolo, Paolo; Shore, Roy E; Koenig, Karen L

doi:10.1186/bcr3117

Breast Cancer Research

Table 3 Odds ratios (ORs) and 95% confidence intervals (CIs) for breast cancer by hormone concentration

From: Premenopausal serum androgens and breast cancer risk: a nested case-control study

	Quintiles					Pfor trend
	1	2	3	4	5
Testosterone
Cutpoints, nmol/L	< 0.50	0.50 to 0.74	0.75 to 0.99	1.00 to 1.41	> 1.41
#cases/#controls^a	58/139	75/124	63/134	70/129	80/118
Unadjusted OR^{b, c} (95% CI)	1.0	1.5 (1.0, 2.3)	1.2 (0.8, 1.9)	1.4 (0.9, 2.2)	1.7 (1.1, 2.7)	0.06
Adjusted OR^{b, c} (95% CI)	1.0	1.5 (0.9, 2.3)	1.2 (0.7, 1.9)	1.4 (0.9, 2.3)	1.8 (1.1, 2.9)	0.04
Adjusted OR^{b, c, d} (95% CI)	1.0	1.6 (1.0, 2.6)	1.4 (0.9, 2.2)	1.6 (1.0, 2.6)	2.2 (1.3, 3.5)	0.03
Free Testosterone
Cutpoints, pmol/L	< 6.02	6.02 to 9.11	9.12 to 13.91	13.92 to 20.92	> 20.92
#cases/#controls^a	60/136	63/134	72/125	69/128	81/116
Unadjusted OR^b (95% CI)	1.0	1.1 (0.7, 1.7)	1.3 (0.9, 2.1)	1.3 (0.8, 2.0)	1.6 (1.0, 2.5)	0.03
Adjusted OR ^{b, c} (95% CI)	1.0	1.2 (0.7, 1.8)	1.5 (0.9, 2.3)	1.5 (0.9, 2.3)	1.8 (1.1, 2.8)	0.01
Adjusted OR^{b, c, d} (95% CI)	1.0	1.3 (0.8, 2.0)	1.5 (1.0, 2.4)	1.4 (0.9, 2.3)	1.9 (1.2, 2.9)	0.01
Androstenedione
Cutpoints, nmol/L	< 2.45	2.45 to 3.37	3.38 to 4.32	4.33 to 5.58	> 5.58
#cases/#controls^a	65/138	72/120	63/139	70/132	80/123
Unadjusted OR^b (95% CI)	1.0	1.2 (0.8, 1.9)	1.1 (0.7, 1.7)	1.2 (0.8, 1.9)	1.5 (1.0, 2.5)	0.11
Adjusted OR ^{b, c} (95% CI)	1.0	1.3 (0.8, 2.0)	1.1 (0.7, 1.7)	1.3 (0.8, 2.1)	1.7 (1.1, 2.7)	0.07
Adjusted OR^{b, c, d} (95% CI)	1.0	1.5 (0.9, 2.4)	1.0 (0.6, 1.6)	1.3 (0.8, 2.2)	1.6 (1.0, 2.7)	0.11
DHEAS
Cutpoints, μmol/L	< 2.04	2.04 to 2.88	2.89 to 3.94	3.95 to 5.24	> 5.24
#cases/#controls^a	64/139	70/134	69/134	80/124	71/132
Unadjusted OR^b (95% CI)	1.0	1.2 (0.8, 1.8)	1.2 (0.7, 1.8)	1.5 (0.9, 2.2)	1.2 (0.8, 1.9)	0.25
Adjusted OR ^{b, c} (95% CI)	1.0	1.1 (0.7, 1.7)	1.1 (0.7, 1.8)	1.5 (0.9, 2.3)	1.3 (0.8, 2.0)	0.14
Adjusted OR^{b, c, d} (95% CI)	1.0	1.1 (0.7, 1.8)	1.1 (0.7, 1.8)	1.3 (0.8, 2.0)	1.3 (0.8, 2.1)	0.20
SHBG
Cutpoints, nmol/L	< 30.5	30.5 to 43.6	43.6 to 54.8	54.8 to 72.9	> 72.9
#cases/#controls^a	71/133	76/129	68/137	74/131	65/140
Unadjusted OR^b (95% CI)	1.0	1.1 (0.8, 1.7)	0.9 (0.6, 1.4)	1.1 (0.7, 1.7)	0.9 (0.6, 1.3)	0.50
Adjusted OR ^{b, c} (95% CI)	1.0	1.1 (0.7, 1.7)	0.9 (0.6, 1.4)	1.1 (0.7, 1.5)	0.9 (0.6, 1.3)	0.37
Adjusted OR^{b, c, d}(95% CI)	1.0	1.0 (0.6, 1.5)	0.9 (0.6, 1.4)	0.9 (0.6, 1.5)	0.7 (0.4, 1.2)	0.19

^aThe number of subjects varies for each hormone depending on the number of the values below the detection limit. ^bControlling for age, date, and phase and day of cycle at blood donation through matching and use of conditional logistic regression. ^cAdjusted for age at menarche (< 12, 12, 13, > 13, missing), family history of breast cancer (no, one affected first-degree relative > 45 yrs old, one affected first degree relative < 45 yrs old or more than one affected first-degree relative), parity/age at first birth (≤20 years at first full-term pregnancy, 21-25 years at first full-term pregnancy, 26-30 years at first full-term pregnancy, > 30 years at first full-term pregnancy, nulliparous, missing), history of breast biopsy, and body mass index (< 20, 20-22.5, 22.6-24.9, 25-29.9, 30+, missing). ^dUsing the average of two measurements for women for whom two blood samples were available and one measurement for all other women and adjusting for all factors listed in ^c. DHEAS, dehydroandrosterone sulfate; SHBG, sex hormone-binding globulin.

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