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Table 3 Odds ratios (ORs) and 95% confidence intervals (CIs) for breast cancer by hormone concentration

From: Premenopausal serum androgens and breast cancer risk: a nested case-control study

  Quintiles Pfor trend
  1 2 3 4 5  
Testosterone       
   Cutpoints, nmol/L < 0.50 0.50 to 0.74 0.75 to 0.99 1.00 to 1.41 > 1.41  
   #cases/#controlsa 58/139 75/124 63/134 70/129 80/118  
   Unadjusted ORb, c (95% CI) 1.0 1.5 (1.0, 2.3) 1.2 (0.8, 1.9) 1.4 (0.9, 2.2) 1.7 (1.1, 2.7) 0.06
   Adjusted ORb, c (95% CI) 1.0 1.5 (0.9, 2.3) 1.2 (0.7, 1.9) 1.4 (0.9, 2.3) 1.8 (1.1, 2.9) 0.04
   Adjusted ORb, c, d (95% CI) 1.0 1.6 (1.0, 2.6) 1.4 (0.9, 2.2) 1.6 (1.0, 2.6) 2.2 (1.3, 3.5) 0.03
Free Testosterone       
   Cutpoints, pmol/L < 6.02 6.02 to 9.11 9.12 to 13.91 13.92 to 20.92 > 20.92  
   #cases/#controlsa 60/136 63/134 72/125 69/128 81/116  
   Unadjusted ORb (95% CI) 1.0 1.1 (0.7, 1.7) 1.3 (0.9, 2.1) 1.3 (0.8, 2.0) 1.6 (1.0, 2.5) 0.03
   Adjusted OR b, c (95% CI) 1.0 1.2 (0.7, 1.8) 1.5 (0.9, 2.3) 1.5 (0.9, 2.3) 1.8 (1.1, 2.8) 0.01
   Adjusted ORb, c, d (95% CI) 1.0 1.3 (0.8, 2.0) 1.5 (1.0, 2.4) 1.4 (0.9, 2.3) 1.9 (1.2, 2.9) 0.01
Androstenedione       
   Cutpoints, nmol/L < 2.45 2.45 to 3.37 3.38 to 4.32 4.33 to 5.58 > 5.58  
   #cases/#controlsa 65/138 72/120 63/139 70/132 80/123  
   Unadjusted ORb (95% CI) 1.0 1.2 (0.8, 1.9) 1.1 (0.7, 1.7) 1.2 (0.8, 1.9) 1.5 (1.0, 2.5) 0.11
   Adjusted OR b, c (95% CI) 1.0 1.3 (0.8, 2.0) 1.1 (0.7, 1.7) 1.3 (0.8, 2.1) 1.7 (1.1, 2.7) 0.07
   Adjusted ORb, c, d (95% CI) 1.0 1.5 (0.9, 2.4) 1.0 (0.6, 1.6) 1.3 (0.8, 2.2) 1.6 (1.0, 2.7) 0.11
DHEAS       
   Cutpoints, μmol/L < 2.04 2.04 to 2.88 2.89 to 3.94 3.95 to 5.24 > 5.24  
   #cases/#controlsa 64/139 70/134 69/134 80/124 71/132  
   Unadjusted ORb (95% CI) 1.0 1.2 (0.8, 1.8) 1.2 (0.7, 1.8) 1.5 (0.9, 2.2) 1.2 (0.8, 1.9) 0.25
   Adjusted OR b, c (95% CI) 1.0 1.1 (0.7, 1.7) 1.1 (0.7, 1.8) 1.5 (0.9, 2.3) 1.3 (0.8, 2.0) 0.14
   Adjusted ORb, c, d (95% CI) 1.0 1.1 (0.7, 1.8) 1.1 (0.7, 1.8) 1.3 (0.8, 2.0) 1.3 (0.8, 2.1) 0.20
SHBG       
   Cutpoints, nmol/L < 30.5 30.5 to 43.6 43.6 to 54.8 54.8 to 72.9 > 72.9  
   #cases/#controlsa 71/133 76/129 68/137 74/131 65/140  
   Unadjusted ORb (95% CI) 1.0 1.1 (0.8, 1.7) 0.9 (0.6, 1.4) 1.1 (0.7, 1.7) 0.9 (0.6, 1.3) 0.50
   Adjusted OR b, c (95% CI) 1.0 1.1 (0.7, 1.7) 0.9 (0.6, 1.4) 1.1 (0.7, 1.5) 0.9 (0.6, 1.3) 0.37
   Adjusted ORb, c, d(95% CI) 1.0 1.0 (0.6, 1.5) 0.9 (0.6, 1.4) 0.9 (0.6, 1.5) 0.7 (0.4, 1.2) 0.19
  1. aThe number of subjects varies for each hormone depending on the number of the values below the detection limit. bControlling for age, date, and phase and day of cycle at blood donation through matching and use of conditional logistic regression. cAdjusted for age at menarche (< 12, 12, 13, > 13, missing), family history of breast cancer (no, one affected first-degree relative > 45 yrs old, one affected first degree relative < 45 yrs old or more than one affected first-degree relative), parity/age at first birth (≤20 years at first full-term pregnancy, 21-25 years at first full-term pregnancy, 26-30 years at first full-term pregnancy, > 30 years at first full-term pregnancy, nulliparous, missing), history of breast biopsy, and body mass index (< 20, 20-22.5, 22.6-24.9, 25-29.9, 30+, missing). dUsing the average of two measurements for women for whom two blood samples were available and one measurement for all other women and adjusting for all factors listed in c. DHEAS, dehydroandrosterone sulfate; SHBG, sex hormone-binding globulin.