PIK3CAmutation impact on survival in breast cancer patients and in ERα, PR and ERBB2-based subgroups

Breast Cancer Research

Table 4 Multivariate Cox analysis of metastasis-free survival in the total population and in subgroups of patients with breast cancer

Variables	Total population		ER⁺ patients		ER^- patients		PR⁺ patients		PR^- patients		ERBB2⁺ patients		ERBB2^- patients
	HR (95% CI)	Pvalue^a	HR (95% CI)	Pvalue^a	HR (95% CI)	Pvalue^a	HR (95% CI)	Pvalue^a	HR (95% CI)	Pvalue^a	HR (95% CI)	Pvalue^a	HR (95% CI)	Pvalue^a
SBR		0.038		0.019		NS		0.00077		NS		NS		0.0043
I	1		1		1		1		1		1		1
II	1.34 (1.02-1.76)		1.45 (1.06-1.98)		1.02 (0.57-1.80)		1.88 (1.30-2.71)		0.93 (0.63-1.38)		0.89 (0.51-1.55)		1.60 (1.16-2.21)
III	1.79 (1.03-3.11)		2.11 (1.13-3.92)		1.03 (0.33-3.26)		3.52 (1.69-7.32)		0.87 (0.40-1.91)		0.79 (0.26-2.39)		2.56 (1.34-4.90)
pN		0.00014		0.00093		NS		0.0068		0.01		0.000049		NS
0	1		1		1		1		1		1		1
1-3	1.58 (1.25-1.99)		1.60 (1.21-2.11)		1.45 (0.94-2.25)		1.61 (1.14-2.27)		1.51 (1.10-2.07)		2.61 (1.63-4.18)		1.26 (0.97-1.66)
> 3	2.48 (1.56-3.96)		2.56 (1.47-4.47)		2.11 (0.88-5.05)		2.59 (1.30-5.18)		2.28 (1.21-4.29)		6.83 (2.67-17.44)		1.60 (0.93-2.74)
pT		0.01		0.00041		NS		0.0023		NS		NS		0.0054
≤ 25 mm	1		1		1		1		1		1		1
> 25 mm	1.53 (1.11-2.13)		2.05 (1.38-3.05)		0.80 (0.44-1.47)		2.09 (1.30-3.36)		1.17 (0.74-1.84)		1.06 (0.54-2.08)		1.72 (1.17-2.52)
ER		NS		-		-		NS		NS		NS		NS
Negative	1		-		-		1		1		1		1
Positive	1.04 (0.68-1.60)		-		-		2.09 (0.28-15.63)		0.82 (0.51-1.32)		0.78 (0.36-1.70)		1.23 (0.71-2.11)
PR		NS		NS		NS		-				NS		NS
Negative	1		1		1		-		-		1		1
Positive	0.77 (0.52-1.14)		0.81 (0.54-1.23)		0.31 (0.04-2.33)		-		-		0.56 (0.23-1.36)		0.79 (0.51-1.23)
ERBB2		NS		NS		NS		NS		NS		-		-
Negative	1		1		1		1		1		-		-
Positive	1.12 (0.77-1.62)		1.01 (0.60-1.70)		1.33 (0.74-2.38)		0.98 (0.50-1.93)		1.17 (0.74-1.85)		-		-
PIK3CA		NS		NS		NS		NS		NS		0.023		NS
Wild-type	1		1		1		1		1		1		1
Mutated	0.75 (0.53-1.07)		0.84 (0.57-1.23)		0.49 (0.19-1.26)		0.62 (0.38-1.01)		0.92 (0.55-1.54)		0.31 (0.12-0.79)		0.96 (0.65-1.44)

^aMultivariate Cox analysis. CI, confidence interval; ER, estrogen receptor; HR, hazard ratio; NS, not significant; PIK3CA, phosphatidylinositol 3-kinase, catalytic, alpha polypeptide gene; pN, number of positive axillary lymph nodes assessed by a pathologist at the time of surgery; PR, progesterone receptor; pT, size of the primery tumor assessed by a patologist at the time of surgery}; SBR, Scarff-Bloom-Richardson classification.

ISSN: 1465-542X