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Table 1 PIK3CA mutation profiles

From: PIK3CAmutation impact on survival in breast cancer patients and in ERα, PR and ERBB2-based subgroups

Exon

Nucleotide

Codon

Number of mutations

9

c.1634A > C

Glu545Ala

2

9

c.1636C > A

Gln546Lys

2

9

c.1624 G > A

Glu542Lys

20

9

c.1634A > G

Glu545Gly

1

9

c.1633 G > A

Glu545Lys

32

9

c.1633 G > C

Glu545Gln

1

9

c.1490A > G

Asn497Ser

1

9

c.1636C > A

Gln546Lys

2

9

c.1637A > C

Gln546Pro

1

9

c.1637A > G

Gln546Arg

2

20

c.3203dupA

Asn1068Lys

2

20

c.3140A > T

His1047Leu

8

20

c.3140A > G

His1047Arg

70

20

c.3132T > A

Asn1044Lys

1

20

c.3145 G > C

Gly1049Arg

2

20

c.3155C > A

Thr1052Lys

1

20

c.[3085 > C(+)3140A > T]

p.[Asp1029His(+)His1047Leu]

1

20

c.[3140A > T(+)3197C > T]

p.[His1047Leu(+)Ala1066Val]

1

9+20

c.[1624 G < A(+)3127A > G]

p.[Glu542Lys(+)Met1043Val]

1

   

Total = 151

  1. PIK3CA, phosphatidylinositol 3-kinase, catalytic, alpha polypeptide gene.