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Table 2 Areas under the receiver operating characteristic curves for different combinations of prediction models.

From: Breast cancer risk prediction and individualised screening based on common genetic variation and breast density measurement

     OLDmodel NEWmodel  
OLDmodel NEWmodel Controls Cases AUC (95%CI)a P-value AUCb AUC (95%CI)a P-value AUCb P-value ΔAUCc
Swe-Gail Swe-Gail, PD, BMI 1672 1739 0.569 (0.550 - 0.588) 3.00 × 10-12 0.602 (0.584 - 0.621) 3.85 × 10-25 1.17 × 10-7
Swe-Gail Swe-Gail, The7 1527 1566 0.548 (0.527 - 0.568) 4.57 × 10-6 0.597 (0.577 - 0.617) 9.98 × 10-21 7.44 × 10-17
Swe-Gail Swe-Gail, The18 1527 1566 0.548 (0.527 - 0.568) 4.57 × 10-6 0.615 (0.595 - 0.634) 1.96 × 10-28 1.54 × 10-18
Swe-Gail, The7 Swe-Gail, The18 1527 1566 0.597 (0.577 - 0.617) 9.98 × 10-21 0.615 (0.595 - 0.634) 1.96 × 10-28 4.69 × 10-4
Swe-Gail Swe-Gail, PD, BMI 856 1017 0.552 (0526 - 0.578) 1.09 × 10-4 0.571 (0.545 - 0.597) 1.06 × 10-7 2.23 × 10-7
Swe-Gail Swe-Gail, PD, BMI, The7 856 1017 0.552 (0526 - 0.578) 1.09 × 10-4 0.604 (0.579 - 0.630) 6.95 × 10-15 1.19 × 10-7
Swe-Gail Swe-Gail, PD, BMI, The18 856 1017 0.552 (0526 - 0.578) 1.09 × 10-4 0.619 (0.594 - 0.644) 6.16 × 10-19 3.24 × 10-9
Swe-Gail,PD,BMI Swe-Gail, PD, BMI, The7 856 1017 0.571 (0.545 - 0.597) 1.06 × 10-7 0.604 (0.579 - 0.630) 6.95 × 10-15 9.50 × 10-9
Swe-Gail, PD, BMI Swe-Gail, PD, BMI, The18 856 1017 0.571 (0.545 - 0.597) 1.06 × 10-7 0.619 (0.594 - 0.644) 6.16 × 10-19 1.93 × 10-9
Swe-Gail, PD, BMI, The7 Swe-Gail, PD, BMI, The18 856 1017 0.604 (0.579 - 0.630) 6.95 × 10-15 0.619 (0.594 - 0.644) 6.16 × 10-19 6.18 × 10-3
  1. a AUC and Confidence Interval (CI) evaluated using Delongs non-parametric estimation.
  2. b Null hypothesis of AUC = 0.5 assessed using Mann-Whitney U test.
  3. c Null hypothesis of ΔAUC = 0 assessed using DeLongs Test.