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Table 1 Effect sizes for the 18 genomic loci, percentage mammographic density, body mass index and clinical risk factors, used for risk prediction.

From: Breast cancer risk prediction and individualised screening based on common genetic variation and breast density measurement

dbSNP No

Chromosome

ORa

Reference First author (Year)

OR (95%CI)b

P c

rs11249433

1

1.12

Turnbull (2010), Thomas (2009)

1.12 (1.00 to 1.25)

4.3 × 10-2

rs1045485

2

1.14

Turnbull (2010), Cox (2007)

1.08 (0.90 to 1.28)

4.1 × 10-1

rs13387042

2

1.15

Turnbull (2010), Thomas (2009), Stacy (2007)

1.21 (1.08 to 1.34)

6.0 × 10-4

rs4973768

3

1.11

Turnbull (2010), Ahmed (2009)

1.04 (0.94 to 1.16)

4.2 × 10-2

rs10941679

5

1.19

Turnbull (2010), Stacy (2007)

1.19 (1.06 to 1.34)

4.0 × 10-3

rs889312

5

1.14

Turnbull (2010), Easton (2007)

1.14 (1.01 to 1.28)

3.5 × 10-2

rs2046210

6

1.27

Turnbull (2010), Zeng (2009)

1.14 (1.01 to 1.27)

2.7 × 10-2

rs13281615

8

1.10

Turnbull (2010), Easton (2007)

1.19 (1.07 to 1.33)

1.6 × 10-3

rs1011970

9

1.09

Turnbull (2010)

1.04 (0.90 to 1.21)

5.5 × 10-1

rs2981582

10

1.26

Turnbull (2010), Easton (2007)

1.28 (1.15 to 1.43)

6.0 × 10-6

rs2380205

10

1.11

Turnbull (2010)

1.04 (0.93 to 1.16)

4.9 × 10-1

rs10995190

10

1.16

Turnbull (2010)

1.12 (0.98 to 1.30)

9.9 × 10-2

rs704010

10

1.07

Turnbull (2010)

1.07 (0.96 to 1.19)

2.5 × 10-1

rs3817198

11

1.07

Turnbull (2010), Thomas (2009), Easton (2007)

1.01 (0.90 to 1.14)

8.1 × 10-1

rs614367

11

1.15

Turnbull (2010)

1.36 (1.18 to 1.58)

8.3 × 10-4

rs999737

14

1.09

Turnbull (2010), Thomas (2009)

1.09 (0.96 to 1.25)

1.9 × 10-2

rs3803662

16

1.20

Turnbull (2010), Thomas (2009), Easton (2007), Stacy (2007)

1.27 (1.13 to 1.43)

1.0 × 10-4

rs6504950

17

1.05

Turnbull (2010), Ahmed (2009)

1.11 (0.98 to 1.25)

1.6 × 10-1

Percentage mammographic density

   

0

 

1.00

Boyd (2006)

  

< 10%

 

1.27

   

10-25

 

2.00

   

25-50

 

2.98

   

50-75

 

3.70

   

≥ 75

 

5.86

   

BMI (body mass Index)

    

< 21.79

 

1.00

Boyd (2006)

  

21.79-23.30

 

1.16

   

23.30-25.02

 

1.13

   

25.02-27.64

 

1.28

   

≥ 27.64

 

1.67

   

Clinical factors

   

Age at menarche

1.10

Gail (1989)

  

Age at first live birth

1.24

Gail (1989)

  

Benign breast disease

1.65

Estimated from Swedish Case-Control Data

  

Family history

2.07

Estimated from Swedish Case-Control Data

  
  1. a Published odds ratio (For SNPs with effect estimates from multiple sources, the inverse variance method was used to obtain a weighted average of effect estimate from the separate studies)
  2. b Per allele odds ratio (per copy of the high-risk allele in the Swedish case-control sample).
  3. c P-values for tests of association based on likelihood-ratio tests, in the current Swedish case-control study.