TY - JOUR AU - Boimel, Pamela J. AU - Smirnova, Tatiana AU - Zhou, Zhen Ni AU - Wyckoff, Jeffrey AU - Park, Haein AU - Coniglio, Salvatore J. AU - Qian, Bin-Zhi AU - Stanley, E. Richard AU - Cox, Dianne AU - Pollard, Jeffrey W. AU - Muller, William J. AU - Condeelis, John AU - Segall, Jeffrey E. PY - 2012 DA - 2012/02/07 TI - Contribution of CXCL12 secretion to invasion of breast cancer cells JO - Breast Cancer Research SP - R23 VL - 14 IS - 1 AB - Neu (HER2/ErbB2) is overexpressed in 25% to 30% of human breast cancer, correlating with a poor prognosis. Researchers in previous studies who used the mouse mammary tumor virus Neu-transgenic mouse model (MMTV-Neu) demonstrated that the Neu-YB line had increased production of CXCL12 and increased metastasis, whereas the Neu-YD line had decreased metastasis. In this study, we examined the role of increased production of CXCL12 in tumor cell invasion and malignancy. SN - 1465-542X UR - https://doi.org/10.1186/bcr3108 DO - 10.1186/bcr3108 ID - Boimel2012 ER -