TY - JOUR AU - Hu, Kaiji AU - Law, Jennifer H. AU - Fotovati, Abbas AU - Dunn, Sandra E. PY - 2012 DA - 2012/02/06 TI - Small interfering RNA library screen identified polo-like kinase-1 (PLK1) as a potential therapeutic target for breast cancer that uniquely eliminates tumor-initiating cells JO - Breast Cancer Research SP - R22 VL - 14 IS - 1 AB - Triple-negative breast cancer (TNBC) high rate of relapse is thought to be due to the presence of tumor-initiating cells (TICs), molecularly defined as being CD44high/CD24-/low. TICs are resilient to chemotherapy and radiation. However, no currently accepted molecular target exists against TNBC and, moreover, TICs. Therefore, we sought the identification of kinase targets that inhibit TNBC growth and eliminate TICs. SN - 1465-542X UR - https://doi.org/10.1186/bcr3107 DO - 10.1186/bcr3107 ID - Hu2012 ER -