Use of glucocorticoids and risk of breast cancer: a Danish population-based case-control study

Breast Cancer Research

Table 2 Number of prescriptions (pres.) and temporality of any glucocorticoid (GC) use, systemic GC use and inhaled GC use and odds ratio of breast cancer

Characteristics	Cases (N= 9,488)		Controls^a (N= 94,876)		Odds Ratio^b	95% Confidence Interval
	N	%	N	%
Any GC use
Never use	6,692	71	68,064	72	reference	reference
Ever use
≤ 2 pres.	1,452	15	13,891	15	1.0	0.98, 1.1
> 2 pres.	1,344	14	12,921	14	1.0	0.96, 1.1
Recent use^c
≤ 2 pres.	284	3.0	2,949	3.1	0.96	0.84, 1.1
3 to 9 pres.	72	0.8	781	0.8	0.93	0.73, 1.2
> 9 pres.	13	0.1	156	0.2	0.82	0.46, 1.4
Former use^d
≤ 2 pres.	1,168	12	10,942	12	1.1	0.99, 1.1
3 to 9 pres.	655	6.9	6,142	6.5	1.0	0.96, 1.1
> 9 pres.	604	6.4	5,842	6.2	1.0	0.93, 1.1
Systemic GC use
Never use of any GC	6,692	71	68,064	72	reference	reference
Only inhaled/local GC use	451	4.8	4,401	4.6	1.0	0.93, 1.1
Ever use of systemic GC
≤ 2 pres.	1,437	15	13,719	15	1.0	0.98, 1.1
> 2 pres.	908	10	8,692	9.1	1.0	0.96, 1.1
Recent systemic use^c
≤ 2 pres.	278	2.9	2,903	3.1	0.95	0.84, 1.1
> 2 pres.	64	0.7	705	0.7	0.91	0.71, 1.2
Former systemic use^d
≤ 2 pres.	1,159	12	10,816	11	1.1	0.99, 1.1
> 2 pres.	844	8.9	7,987	8.4	1.0	0.96, 1.1
Inhaled GC use
Never use of any GC	6,692	71	68,064	72	reference	reference
Only systemic/local GC use	1,886	20	17,951	19	1.0	0.98, 1.1
Ever users of inhaled GC
≤ 2 pres.	317	3.4	3,223	3.4	1.0	0.87, 1.1
> 2 pres.	593	6.2	5,638	6.0	1.0	0.95, 1.1
Recent inhaled use^c
≤ 2 pres.	84	0.9	770	0.8	1.1	0.86, 1.4
> 2 pres.	38	0.4	453	0.5	0.83	0.59, 1.2
Former inhaled use^d
≤ 2 pres.	233	2.5	2,453	2.6	0.94	0.82, 1.1
> 2 pres.	555	5.8	5,185	5.5	1.1	0.97, 1.2

^aControls were matched to cases on county of residence and birth year. ^bAnalysis adjusted for any use of postmenopausal hormone replacement therapy or 'other immunosuppressive drugs' before index date, and any hospital diagnosis of obesity, diabetes (+/- metformin use), chronic obstructive pulmonary disease, asthma, inflammatory bowel disease, rheumatoid arthritis or 'other autoimmune disease' before index date. ^cRecent use: gucocorticoid use only within two years of diagnosis, and never a former user. ^dFormer use: Glucocorticoid use earlier than within two years of diagnosis.

ISSN: 1465-542X