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Table 4 Cumulative effects of associated SNPs and clinical risk factors on the risk of breast cancer in all samples

From: Breast cancer risk assessment with five independent genetic variants and two risk factors in Chinese women

Risk models TS + VS sets Adjusted ORc
(95% CI)
P c Pfor trendc
  Cases (%) Controls (%)    
Counts of risk alleles a      
0 to 1 187 (11.08) 295 (16.70) 1.00 (ref.)   
2 327 (19.37) 408 (23.10) 1.25 (0.98 to 1.60) 7.04E-02  
3 472 (27.96) 503 (28.48) 1.48 (1.18 to 1.87) 8.04E-04  
4 404 (23.93) 351 (19.88) 1.85 (1.45 to 2.35) 6.03E-07  
5 201 (11.91) 152 (8.61) 2.09 (1.56 to 2.79) 6.76E-07  
≥ 6 97 (5.75) 57 (3.23) 2.67 (1.81 to 3.93) 6.40E-07 2.27E-12
Counts of risk factors b      
0 to 2 109 (6.61) 277 (15.79) 1.00 (ref.)   
3 203 (12.31) 344 (19.61) 1.54 (1.16 to 2.04) 3.08E-03  
4 335 (20.32) 386 (22.01) 2.28 (1.75 to 2.99) 1.54E-09  
5 346 (20.98) 377 (21.49) 2.47 (1.89 to 3.23) 4.11E-11  
6 338 (20.50) 219 (12.49) 4.19 (3.15 to 5.56) 4.07E-23  
≥ 7 318 (19.28) 151 (8.61) 5.61 (4.16 to 7.56) 1.03E-29 3.76E-40
Genetic risk score a      
0 (< Q25) 349 (20.68) 487 (27.58) 1.00 (ref.)   
1(Q25 to Q50) 406 (24.05) 499 (28.26) 1.21 (0.99 to 1.48) 6.96E-02  
2 (Q50 to Q75) 436 (25.83) 405 (22.93) 1.57 (1.28 to 1.93) 1.74E-05  
3 (≥ Q75) 497 (29.44) 375 (21.23) 1.91 (1.56 to 2.35) 5.60E-10 2.02E-11
Genetic & clinical risk score b     
0 (< Q25) 167 (10.13) 437 (24.91) 1.00 (ref.)   
1 (Q25 to Q50) 332 (20.13) 442 (25.20) 2.01 (1.60 to 2.53) 2.68E-09  
2 (Q50 to Q75) 406 (24.62) 438 (24.97) 2.55 (2.03 to 3.20) 6.66E-16  
3 (≥ Q75) 744 (45.12) 437 (24.91) 4.73 (3.80 to 5.88) 2.38E-44 2.27E-47
  1. a Based on the five SNPs; b Based on five SNPs and two risk factors; c Adjust for age, age at menarche, menopausal status and age at first live birth where was appropriate.