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Table 3 Association of SNPs with breast cancer risk in both testing and validation sets

From: Breast cancer risk assessment with five independent genetic variants and two risk factors in Chinese women

Genotype Testing Set, TS.
(n= 1,779)
Validation Set, VS.
(n= 1,881)
Adjusted OR
(95% CI)a
P a Adjusted OR
(95% CI)b
P b Adjusted OR
(95% CI)c
P c
  Case (%)
(n= 878)
Control (%)
(n= 900)
Cases (%)
(n= 914)
Controls (%)
(n= 967)
      
2q35: rs13387042          
GG 627 (72.74) 695 (77.91) 712 (78.33) 773 (80.60) 1.00 (ref.)   1.00 (ref.)   1.00 (ref.)  
GA 223 (25.87) 188 (21.08) 181 (19.91) 178 (18.56) 1.29 (1.03 to 1.63) 0.030 1.21 (0.93 to 1.56) 0.155 1.23 (1.04 to 1.46) 0.018
AA 12 (1.39) 9 (1.01) 16 (1.76) 8 (0.83) 1.46 (0.60 to 3.54) 0.407 2.56 (1.03 to 6.38) 0.044 1.95 (1.04 to 3.66) 0.037
GA/AA 235 (27.26) 197 (22.09) 197 (21.67) 186 (19.40) 1.30 (1.04 to 1.63) 0.023 1.27 (0.99 to 1.63) 0.064 1.26 (1.07 to 1.49) 0.006
A allelic trend (Additive model)    1.30 (1.05 to 1.62) 0.017 1.21 (0.97 to 1.51) 0.085 1.25 (1.07 to 1.46) 0.004
3q24.1: rs2307032          
CC 265 (30.78) 327 (37.16) 288 (31.58) 326 (34.42) 1.00 (ref.)   1.00 (ref.)   1.00 (ref.)  
CT 436 (50.64) 398 (45.23) 429 (47.04) 464 (49.00) 1.31 (1.05 to 1.63) 0.016 1.09 (0.87 to 1.37) 0.459 1.20 (1.02 to 1.40) 0.027
TT 160 (18.58) 155 (17.61) 195 (21.38) 157 (16.58) 1.27 (0.95 to 1.69) 0.105 1.43 (1.06 to 1.91) 0.018 1.36 (1.11 to 1.66) 0.003
CT/TT 596 (69.22) 553 (62.84) 624 (68.42) 621 (65.58) 1.30 (1.06 to 1.60) 0.014 1.18 (0.95 to 1.46) 0.138 1.24 (1.07 to 1.44) 0.005
T allelic trend (Additive model)    1.11 (0.97 to 1.27) 0.122 1.17 (1.02 to 1.34) 0.025 1.14 (1.04 to 1.26) 0.006
6q22.33: rs2180341          
AA 423 (49.76) 480 (54.55) 479 (52.64) 541 (56.53) 1.00 (ref.)   1.00 (ref.)   1.00 (ref.)  
AG 373 (43.88) 334 (37.95) 380 (41.76) 350 (36.57) 1.29 (1.05 to 1.59) 0.016 1.26 (1.02 to 1.56) 0.033 1.28 (1.10 to 1.48) 0.001
GG 54 (6.35) 66 (7.50) 51 (5.60) 66 (6.90) 0.96 (0.64 to 1.43) 0.847 0.87 (0.57 to 1.32) 0.505 0.93 (0.70 to 1.24) 0.614
AG/GG 427 (50.24) 400 (45.45) 431 (47.36) 416 (43.47) 1.24 (1.01 to 1.51) 0.036 1.20 (0.97 to 1.47) 0.086 1.22 (1.06 to 1.40) 0.006
G allelic trend (Additive model)    1.10 (0.94 to 1.29) 0.222 1.06 (0.90 to 1.24) 0.496 1.08 (0.97 to 1.20) 0.174
6q25.1: rs2046210          
GG 290 (33.68) 387 (43.48) 292 (32.19) 380 (39.58) 1.00 (ref.)   1.00 (ref.)   1.00 (ref.)  
GA 413 (47.97) 393 (44.16) 460 (50.72) 443 (46.15) 1.46 (1.17 to 1.81) 6.31 × 10to 4 1.38 (1.10 to 1.73) 4.81 × 10-3 1.43 (1.23 to 1.67) 5.12 × 10-6
AA 158 (18.35) 110 (12.36) 155 (17.09) 137 (14.27) 2.05 (1.52 to 2.76) 2.95 × 10-6 1.54 (1.13 to 2.09) 5.76 × 10-3 1.79 (1.45 to 2.22) 7.13 × 10-8
GA/AA 571 (66.32) 503 (56.52) 615 (67.81) 580 (60.42) 1.59 (1.29 to 1.94) 8.52 × 10-6 1.42 (1.15 to 1.76) 1.27 × 10-3 1.51 (1.31 to 1.75) 2.40 × 10-8
A allelic trend (Additive model)    1.41 (1.22 to 1.62) 1.54E-06 1.24 (1.08 to 1.43) 2.27E-03 1.33 (1.20 to 1.46) 1.92E-08
10q26.13: rs2981582          
CC 362 (41.51) 420 (46.88) 370 (41.29) 464 (48.95) 1.00 (ref.)   1.00 (ref.)   1.00 (ref.)  
CT 400 (45.87) 388 (43.30) 420 (46.88) 408 (43.04) 1.25 (1.01 to 1.53) 3.85 × 10-2 1.20 (0.97 to 1.49) 9.84 × 10-2 1.24 (1.07 to 1.44) 4.40 × 10-3
TT 110 (12.61) 88 (9.82) 106 (11.83) 76 (8.02) 1.49 (1.07 to 2.08) 1.76 × 10-2 1.82 (1.27 to 2.62) 1.19 × 10-3 1.65 (1.29 to 2.10) 5.75 × 10-5
CT/TT 510 (58.49) 476 (53.13) 526 (58.71) 484 (51.05) 1.29 (1.06 to 1.57) 1.15 × 10-2 1.29 (1.05 to 1.59) 9.84 × 10-2 1.31 (1.14 to 1.50) 1.96 × 10-4
T allelic trend (Additive model)    1.23 (1.07 to 1.42) 0.005 1.30 (1.12-1.51) 0.0005 1.27 (1.15 to 1.41) 4.89E-06
  1. Results by logistic regression a in Testing Set, b in Validation Set, c in both Testing and Validation Set; a, b, c Adjust for age, age at menarche, menopausal status and age at first live birth.