Table 3 Association of SNPs with breast cancer risk in both testing and validation sets

GG

627 (72.74)

695 (77.91)

712 (78.33)

773 (80.60)

1.00 (ref.)

1.00 (ref.)

1.00 (ref.)

GA

223 (25.87)

188 (21.08)

181 (19.91)

178 (18.56)

1.29 (1.03 to 1.63)

0.030

1.21 (0.93 to 1.56)

0.155

1.23 (1.04 to 1.46)

0.018

AA

12 (1.39)

9 (1.01)

16 (1.76)

8 (0.83)

1.46 (0.60 to 3.54)

0.407

2.56 (1.03 to 6.38)

0.044

1.95 (1.04 to 3.66)

0.037

GA/AA

235 (27.26)

197 (22.09)

197 (21.67)

186 (19.40)

1.30 (1.04 to 1.63)

0.023

1.27 (0.99 to 1.63)

0.064

1.26 (1.07 to 1.49)

0.006

1.30 (1.05 to 1.62)

0.017

1.21 (0.97 to 1.51)

0.085

1.25 (1.07 to 1.46)

0.004

CC

265 (30.78)

327 (37.16)

288 (31.58)

326 (34.42)

1.00 (ref.)

1.00 (ref.)

1.00 (ref.)

CT

436 (50.64)

398 (45.23)

429 (47.04)

464 (49.00)

1.31 (1.05 to 1.63)

0.016

1.09 (0.87 to 1.37)

0.459

1.20 (1.02 to 1.40)

0.027

TT

160 (18.58)

155 (17.61)

195 (21.38)

157 (16.58)

1.27 (0.95 to 1.69)

0.105

1.43 (1.06 to 1.91)

0.018

1.36 (1.11 to 1.66)

0.003

CT/TT

596 (69.22)

553 (62.84)

624 (68.42)

621 (65.58)

1.30 (1.06 to 1.60)

0.014

1.18 (0.95 to 1.46)

0.138

1.24 (1.07 to 1.44)

0.005

1.11 (0.97 to 1.27)

0.122

1.17 (1.02 to 1.34)

0.025

1.14 (1.04 to 1.26)

0.006

AA

423 (49.76)

480 (54.55)

479 (52.64)

541 (56.53)

1.00 (ref.)

1.00 (ref.)

1.00 (ref.)

AG

373 (43.88)

334 (37.95)

380 (41.76)

350 (36.57)

1.29 (1.05 to 1.59)

0.016

1.26 (1.02 to 1.56)

0.033

1.28 (1.10 to 1.48)

0.001

GG

54 (6.35)

66 (7.50)

51 (5.60)

66 (6.90)

0.96 (0.64 to 1.43)

0.847

0.87 (0.57 to 1.32)

0.505

0.93 (0.70 to 1.24)

0.614

AG/GG

427 (50.24)

400 (45.45)

431 (47.36)

416 (43.47)

1.24 (1.01 to 1.51)

0.036

1.20 (0.97 to 1.47)

0.086

1.22 (1.06 to 1.40)

0.006

1.10 (0.94 to 1.29)

0.222

1.06 (0.90 to 1.24)

0.496

1.08 (0.97 to 1.20)

0.174

GG

290 (33.68)

387 (43.48)

292 (32.19)

380 (39.58)

1.00 (ref.)

1.00 (ref.)

1.00 (ref.)

GA

413 (47.97)

393 (44.16)

460 (50.72)

443 (46.15)

1.46 (1.17 to 1.81)

6.31 × 10^{to 4}

1.38 (1.10 to 1.73)

4.81 × 10^-3

1.43 (1.23 to 1.67)

5.12 × 10^-6

AA

158 (18.35)

110 (12.36)

155 (17.09)

137 (14.27)

2.05 (1.52 to 2.76)

2.95 × 10^-6

1.54 (1.13 to 2.09)

5.76 × 10^-3

1.79 (1.45 to 2.22)

7.13 × 10^-8

GA/AA

571 (66.32)

503 (56.52)

615 (67.81)

580 (60.42)

1.59 (1.29 to 1.94)

8.52 × 10^-6

1.42 (1.15 to 1.76)

1.27 × 10^-3

1.51 (1.31 to 1.75)

2.40 × 10^-8

1.41 (1.22 to 1.62)

1.54E-06

1.24 (1.08 to 1.43)

2.27E-03

1.33 (1.20 to 1.46)

1.92E-08

CC

362 (41.51)

420 (46.88)

370 (41.29)

464 (48.95)

1.00 (ref.)

1.00 (ref.)

1.00 (ref.)

CT

400 (45.87)

388 (43.30)

420 (46.88)

408 (43.04)

1.25 (1.01 to 1.53)

3.85 × 10^-2

1.20 (0.97 to 1.49)

9.84 × 10^-2

1.24 (1.07 to 1.44)

4.40 × 10^-3

TT

110 (12.61)

88 (9.82)

106 (11.83)

76 (8.02)

1.49 (1.07 to 2.08)

1.76 × 10^-2

1.82 (1.27 to 2.62)

1.19 × 10^-3

1.65 (1.29 to 2.10)

5.75 × 10^-5

CT/TT

510 (58.49)

476 (53.13)

526 (58.71)

484 (51.05)

1.29 (1.06 to 1.57)

1.15 × 10^-2

1.29 (1.05 to 1.59)

9.84 × 10^-2

1.31 (1.14 to 1.50)

1.96 × 10^-4

1.23 (1.07 to 1.42)

0.005

1.30 (1.12-1.51)

0.0005

1.27 (1.15 to 1.41)

4.89E-06