Table 3 Summary of the STAT1 staining results in the estrogen receptor-negative human breast cancer cohort stratified by HER2 status
From: STAT1-deficient mice spontaneously develop estrogen receptor α-positive luminal mammary carcinomas
Number (percentage) | ||||
|---|---|---|---|---|
All ER- cases | HER2- | HER2+ | ||
Characteristics | ( n = 78) | ( n = 46) | ( n = 32) | P value |
Percentage of STAT1+ neoplastic cells (percentage score) | ||||
< 5% | 7 (9%) | 4 (9%) | 3 (10%) | |
5%-25% | 10 (13%) | 8 (17%) | 2 (6%) | 0.14a |
26%-75% | 33 (42%) | 22 (48%) | 11 (34%) | |
> 75% | 28 (36%) | 12 (26%) | 16 (50%) | |
Percentage of STAT1+ stromal cells (percentage score) | ||||
< 5% | 0 (0%) | 0 (0%) | 0 (0%) | |
5%-25% | 2 (3%) | 2 (4%) | 0 (0%) | 0.2a |
26%-75% | 26 (33%) | 18 (39%) | 8 (25%) | |
> 75% | 50 (64%) | 26 (57%) | 24 (75%) | |
STAT1 intensity in STAT1+ neoplastic cells (intensity score) | ||||
Low | 17 (22%) | 10 (22%) | 7 (22%) | |
Intermediate | 31 (40%) | 19 (41%) | 12 (38%) | 0.96b |
High | 30 (38%) | 17 (37%) | 13 (40%) | |
STAT1 intensity in STAT1+ stromal cells (intensity score) | ||||
Low | 0 (0%) | 0 (0%) | 0 (0%) | |
Intermediate | 3 (4%) | 0 (0%) | 3 (10%) | 0.07a |
High | 75 (96%) | 46 (100%) | 29 (90%) | |