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Table 3 Summary of the STAT1 staining results in the estrogen receptor-negative human breast cancer cohort stratified by HER2 status

From: STAT1-deficient mice spontaneously develop estrogen receptor α-positive luminal mammary carcinomas

  Number (percentage)  
  All ER- cases HER2- HER2+  
Characteristics ( n = 78) ( n = 46) ( n = 32) P value
Percentage of STAT1+ neoplastic cells (percentage score)     
   < 5% 7 (9%) 4 (9%) 3 (10%)  
   5%-25% 10 (13%) 8 (17%) 2 (6%) 0.14a
   26%-75% 33 (42%) 22 (48%) 11 (34%)  
   > 75% 28 (36%) 12 (26%) 16 (50%)  
Percentage of STAT1+ stromal cells (percentage score)     
   < 5% 0 (0%) 0 (0%) 0 (0%)  
   5%-25% 2 (3%) 2 (4%) 0 (0%) 0.2a
   26%-75% 26 (33%) 18 (39%) 8 (25%)  
   > 75% 50 (64%) 26 (57%) 24 (75%)  
STAT1 intensity in STAT1+ neoplastic cells (intensity score)     
   Low 17 (22%) 10 (22%) 7 (22%)  
   Intermediate 31 (40%) 19 (41%) 12 (38%) 0.96b
   High 30 (38%) 17 (37%) 13 (40%)  
STAT1 intensity in STAT1+ stromal cells (intensity score)     
   Low 0 (0%) 0 (0%) 0 (0%)  
   Intermediate 3 (4%) 0 (0%) 3 (10%) 0.07a
   High 75 (96%) 46 (100%) 29 (90%)  
  1. aFisher exact test. bChi-squared test. ER, estrogen receptor; HER2, human epidermal growth factor receptor 2.