Tibolone increases bone mineral density but also relapse in breast cancer survivors: LIBERATE trial bone substudy

Breast Cancer Research

Table 2 Factors predicting bone mineral density (lumbar spine and total hip)

		Numerator	Denominator
End point	Effect	DF	DF	Fvalue	Pvalue
Lumbar spine	Race	2	665	26.19	< 0.0001
	BMI	1	665	17.06	< 0.0001
	Time since breast surgery (years)	1	665	7.74	0.006
	AGE	1	665	6.32	0.012
	Age at menarche (years)	1	665	4.74	0.030
	Node status	1	665	4.77	0.029
	GnRH analogues	2	665	3.26	0.039
Total hip	Race	2	660	63.33	< 0.0001
	BMI	1	660	149.15	< 0.0001
	Time since breast surgery (years)	1	660	6.15	0.013
	AGE	1	660	4.81	0.029

Factors predicting bone mineral density (BMD) at baseline. Asian women show significantly more osteoporosis (P ≤ 0.001) at both hip and lumbar spine. Older age and lower BMI, both of which are recognized to predict BMD, were also significant.

ISSN: 1465-542X