Table 4 David Enriched Gene Ontology Categories in Genes Expressed Differently between patient tumors and xenografts
From: Molecular profiling of patient-derived breast cancer xenografts
Gene Ontology Biologic Process | Count | % | List Total | Fold Enrichment | Benjamini |
|---|---|---|---|---|---|
immune response | 98 | 16.2 | 479 | 4.01 | 8.12E-30 |
cell adhesion | 94 | 15.6 | 479 | 3.79 | 9.26E-27 |
biologic adhesion | 94 | 15.6 | 479 | 3.79 | 6.90E-27 |
response to wounding | 80 | 13.2 | 479 | 4.26 | 7.08E-26 |
defense response | 72 | 11.9 | 479 | 3.31 | 1.51E-16 |
inflammatory response | 49 | 8.1 | 479 | 4.26 | 7.35E-15 |
blood vessel development | 41 | 6.8 | 479 | 4.73 | 1.62E-13 |
vasculature development | 41 | 6.8 | 479 | 4.61 | 2.48E-13 |
extracellular matrix organization | 26 | 4.3 | 479 | 7.06 | 4.28E-12 |
positive regulation of immune system process | 35 | 5.8 | 479 | 4.15 | 8.12E-10 |
extracellular structure organization | 28 | 4.6 | 479 | 4.85 | 4.15E-09 |
wound healing | 30 | 5.0 | 479 | 4.44 | 6.13E-09 |
blood vessel morphogenesis | 31 | 5.1 | 479 | 4.15 | 1.38E-08 |
positive regulation of response to stimuli | 32 | 5.3 | 479 | 3.83 | 4.73E-08 |
regulation of response to external stimulus | 26 | 4.3 | 479 | 4.62 | 5.46E-08 |
taxis | 26 | 4.3 | 479 | 4.59 | 5.87E-08 |
chemotaxis | 26 | 4.3 | 479 | 4.59 | 5.87E-08 |
angiogenesis | 25 | 4.1 | 479 | 4.77 | 5.70E-08 |
regulation of cell activation | 27 | 4.5 | 479 | 4.36 | 7.17E-08 |
regulation of cell migration | 26 | 4.3 | 479 | 4.34 | 1.61E-07 |
skeletal system development | 36 | 6.0 | 479 | 3.19 | 3.25E-07 |
regulation of locomotion | 27 | 4.5 | 479 | 3.97 | 4.70E-07 |
regulation of cell motion | 27 | 4.5 | 479 | 3.95 | 5.01E-07 |
regulation of T cell activation | 21 | 3.5 | 479 | 5.07 | 4.87E-07 |