Stability of CGH profiles between primary and metastasis profiles and throughout successive xenograft generations. A, aCGH profile of the HBCx-13 tumors derived from a patient's primary breast tumor (upper), breast tumor-derived xenograft (middle), and axillary metastasis-derived xenograft (bottom). B, details of the aCGH profile of chromosome 17 amplicon (containing the HER2 oncogene amplification and chromosome 8 amplicon. C, aCGH profiles of the luminal HBC-21 patient tumor and xenografts from different in vivo tumor passages (p6 corresponding to a time lapse of 30 months after the first tumor engraftment). aCGH, array comparative genomic hybridization; HBC, human breast cancer; HBC-n, HBC primary tumor n; HBCx-n, HBC xenograft tumor n; HER2, human epidermal growth factor receptor 2.